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Chemical Structure| 943320-53-4 Chemical Structure| 943320-53-4

Structure of 943320-53-4

Chemical Structure| 943320-53-4

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Product Details of [ 943320-53-4 ]

CAS No. :943320-53-4
Formula : C9H6N2
M.W : 142.16
SMILES Code : C#CC1=CN=C2C=CC=CN12
MDL No. :MFCD17012026
InChI Key :FBTDPECEFKOJQL-UHFFFAOYSA-N
Pubchem ID :46838759

Safety of [ 943320-53-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 943320-53-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 943320-53-4 ]

[ 943320-53-4 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 307503-19-1 ]
  • [ 1066-54-2 ]
  • [ 943320-53-4 ]
YieldReaction ConditionsOperation in experiment
72% With copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; triethylamine In acetonitrile for 3 h; Inert atmosphere; Reflux In a 500 mL three-necked flask,Under nitrogen protection conditions,3-iodoimidazo [1,2-a] pyridine (10.0 g, 41.0 mmol)PdCl2 (pph3) 2 (0.6 g, 0.8 mmol),CuI (0.2 g, 0.8 mmol) was successively added to anhydrous acetonitrile (200 mL)Then Et3N (12.4 g, 122.9 mmol)And trimethylsilylacetylene (12.1 g, 122.9 mmol)Reflux reaction 3h. Reaction is completed, suction filter,The filtrate was evaporated under reduced pressure,The residue was dissolved in methanol (150 mL)Anhydrous potassium carbonate (22.7 g, 163.9 mmol) was added at room temperature for 30 min,Filter, the filtrate vacuum distillation solvent was crude,The crude product was subjected to silica gel column (mobile phase: PE: EA = 20: 1) to give 4.2 g of 3-acetimidazo [1,2-a] pyridine as a white solid in 72percent yield.
References: [1] Patent: CN107163042, 2017, A, . Location in patent: Paragraph 0023; 0024; 0025; 0034; 0035; 0036; 0045; 0046.
  • 2
  • [ 4926-47-0 ]
  • [ 1066-54-2 ]
  • [ 943320-53-4 ]
References: [1] Patent: WO2013/162727, 2013, A1, . Location in patent: Page/Page column 59.
[2] Patent: WO2014/145022, 2014, A1, . Location in patent: Page/Page column 49.
  • 3
  • [ 274-76-0 ]
  • [ 943320-53-4 ]
References: [1] Patent: CN103420977, 2016, B, .
[2] Patent: CN107163042, 2017, A, .
[3] Patent: CN104341425, 2018, B, .
  • 4
  • [ 307503-19-1 ]
  • [ 943320-53-4 ]
References: [1] Patent: CN103420977, 2016, B, .
[2] Patent: CN104341425, 2018, B, .
  • 5
  • [ 4926-47-0 ]
  • [ 943320-53-4 ]
References: [1] Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 10033 - 10046.
  • 6
  • [ 504-29-0 ]
  • [ 943320-53-4 ]
References: [1] Patent: CN107163042, 2017, A, .
 

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