Home Cart Sign in  
Chemical Structure| 93376-18-2 Chemical Structure| 93376-18-2

Structure of 93376-18-2

Chemical Structure| 93376-18-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 93376-18-2 ]

CAS No. :93376-18-2
Formula : C21H16N2O2
M.W : 328.36
SMILES Code : O=C(C1=CC=CC(C2=C(C#N)C#N)=C1C3=C2C=CC=C3)OCCCC

Safety of [ 93376-18-2 ]

Application In Synthesis of [ 93376-18-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 93376-18-2 ]

[ 93376-18-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 110-89-4 ]
  • n-butyl 9-fluorenone-4-carboxylate ester [ No CAS ]
  • [ 6223-83-2 ]
  • [ 109-77-3 ]
  • [ 71-36-3 ]
  • [ 93376-18-2 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; sodium hydrogencarbonate; In methanol; water; acetone; toluene; Preparation Example 5 Preparation of Compound (26) The following is a description of the preparation of a dicyanofluorene-based compound Compound (26) to be used as an ETM in Comparative Example 1. A mixture of 70 g (0.312 mole) of <strong>[6223-83-2]9-fluorenone-4-carboxylic acid</strong> (from Sigma-Aldrich, Milwaukee, Wis.), 480 g (6.5 mole) of n-butanol (manufactured from Fisher Scientific Company Inc., Hanover Park, Ill.), 1000 ml of toluene, and 4 ml of concentrated sulfuric acid were added to a 2-liter round bottom flask equipped with a mechanical stirrer and a reflux condenser with a Dean Stark apparatus. With aggressive agitation, the solution was refluxed for 5 hours, during which time about 6 g of water was collected in the Dean Stark apparatus. After refluxing, the flask was cooled to room temperature. The solvents were evaporated and the residue was added with agitation to 4-liter of a 3% aqueous solution of sodium bicarbonate. The solid was filtered off, washed with water until the pH of the washed water was neutral, and dried under a hood overnight. The product was n-butyl 9-fluorenone-4-carboxylate ester. The yield was 70 g (80%). A mixture of 70 g (0.25 mole) of n-butyl 9-fluorenone-4-carboxylate ester, 750 ml of absolute methanol, 37 g (0.55 mole) of malononitrile (from Sigma-Aldrich, Milwaukee, Wis.), 20 drops of piperidine (from Sigma-Aldrich, Milwaukee, Wis.) was added to a 2-liter, 3-neck round bottom flask equipped with a mechanical stirrer and a reflux condenser. The solution was refluxed for 8 hours and the flask was cooled to room temperature. The orange crude product was filtered, washed twice with 70 ml of methanol and once with 150 ml of water, and dried overnight in a hood. This orange crude product was recrystallized from a mixture of 600 ml of acetone and 300 ml of methanol using activated charcoal. The flask was placed at 0 C. for 16 hours. The crystals formed were filtered and dried in a vacuum oven at 50 C. for 6 hours to obtain 60 g of pure (4-n-butoxycarbonyl-9-fluorenylidene)malononitrile (Compound (26)).
  • 2
  • [ 863305-32-2 ]
  • [ 6223-83-2 ]
  • [ 93376-18-2 ]
YieldReaction ConditionsOperation in experiment
80% With sulfuric acid; In water; Preparation of (4-n-Butoxycarbonyl-9-fluorenylidene)malononitrile A 460 g quantity of concentrated sulfuric acid (4.7 moles, analytical grade, from Sigma-Aldrich, Milwaukee, WI) and 100 g of diphenic acid (0.41 mole, from Acros Fisher Scientific Company Inc., Hanover Park, IL) were added to a 1-liter 3-neck round bottom flask, equipped with a thermometer, mechanical stirrer and reflux condenser. Using a heating mantle, the flask was heated to 135-145 C for 12 minutes. After cooling to room temperature, the solution was added to a 4-liter Erlenmeyer flask containing 3 liter of water. The mixture was stirred mechanically and brought to a gentle boil for one hour. The yellow solid that formed was filtered out hot, washed with hot water until the pH of the washing water was neutral, and dried overnight in the fume-hood. The yellow solid was fluorenone-4-carboxylic acid (75 g, 80% yield). The product had a melting point of 223-224 C. The 1H NMR spectrum (300 MHz) of the product in CDCl3 was characterized by the following chemical shifts (delta, ppm): 7.39-7.50 (m, 2H); 7.79 - 7.70 (q, 2H); 7.74 - 7.85 (d, 1H); 7.88 -8.00 (d, 1H); and 8.18 - 8.30 (d, 1H), where d is doublet, t is triplet, m is multiplet; dd is double doublet, q is quintet.
 

Historical Records