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Chemical Structure| 931105-81-6 Chemical Structure| 931105-81-6

Structure of 931105-81-6

Chemical Structure| 931105-81-6

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Product Details of [ 931105-81-6 ]

CAS No. :931105-81-6
Formula : C11H6ClF2N3O
M.W : 269.64
SMILES Code : O=C(C1=NC=CN=C1Cl)NC2=CC=C(F)C=C2F
MDL No. :MFCD28099597

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Application In Synthesis of [ 931105-81-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 931105-81-6 ]

[ 931105-81-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 367-25-9 ]
  • [ 27398-39-6 ]
  • [ 931105-81-6 ]
YieldReaction ConditionsOperation in experiment
53% Example 41; 3-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)pyrazine-2-carboxamide, bis(trifluoroacetic acid) salt; A) 3-Chloro-N-(2,4-difluorophenyl)pyrazine-2-carboxamide; To a mixture of <strong>[27398-39-6]3-chloropyrazine-2-carboxylic acid</strong> (Tyger Scientific, 500 mg, 3.15 mmol) in methylene chloride (30 mL) and DMF (0.1 mL) was added oxalyl chloride (593 mg, 4.7 mmol). After stirring 30 min the reaction mixture was concentrated in vacuo. The residue was taken up in acetonitrile (12 mL) and was treated with triethylamine (920 mg, 9.1 mmol) and 2,4-difluoroaniline (430 mg, 3.3 mmol) and stirred 30 min. The reaction mixture was partitioned between ethyl acetate and brine. The organic layer was washed with brine, dried over anhydrous MgSO4, and then concentrated in vacuo. The resulting solid was recrystallized (ethyl acetate/hexanes) to give the amide (455 mg, 53percent) as a solid. MS(ESI+) m/z 270 (M+H)+.
 

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