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CAS No. : | 929617-35-6 | MDL No. : | MFCD11518975 |
Formula : | C6H4BrN3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | AVTKMQORQDZRPF-UHFFFAOYSA-N |
M.W : | 198.02 | Pubchem ID : | 45789778 |
Synonyms : |
|
Num. heavy atoms : | 10 |
Num. arom. heavy atoms : | 9 |
Fraction Csp3 : | 0.0 |
Num. rotatable bonds : | 0 |
Num. H-bond acceptors : | 2.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 41.59 |
TPSA : | 41.57 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.44 cm/s |
Log Po/w (iLOGP) : | 0.97 |
Log Po/w (XLOGP3) : | 1.51 |
Log Po/w (WLOGP) : | 1.72 |
Log Po/w (MLOGP) : | 0.68 |
Log Po/w (SILICOS-IT) : | 2.28 |
Consensus Log Po/w : | 1.43 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.69 |
Solubility : | 0.409 mg/ml ; 0.00207 mol/l |
Class : | Soluble |
Log S (Ali) : | -1.99 |
Solubility : | 2.02 mg/ml ; 0.0102 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -3.4 |
Solubility : | 0.0797 mg/ml ; 0.000403 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.97 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
59% | at 20℃; | To a solutionof 27(4.00 g, 21.4 mmol) in AcOH (300 ml) was added NaNO2 (1.48 g, 21.4mmol) and stirred overnight at roomtemperature. The reaction mixture was concentrated in vacuo. The residue was diluted with EtOAc and washed with saturatedNaHCO3 aqueous solution and brine. Theorganic layer was dried over anhydrous MgSO4 and reduced underpressure. The residue was purified bysilica gel column chromatography (0-50percent EtOAc in hexanes) to afford 28 as a yellow solid (2.48 g, 59percentyield).1H NMR (300 MHz, CDCl3): δ ppm7.86 - 7.90 (m, 1 H), 8.09 - 8.14 (m, 1 H), 8.83 - 8.88 (m, 1 H).MS ESI/APCI Dual m/z: 198 [M+H] . |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With dmap; In dichloromethane; for 12.33h; | A suspension of 5-bromo-lH-pyrazolo[3,4-c]pyridine (760 mg, 3.80 mmol) in DCM (10 mL) was treated with DMAP (50 mg, 0.41 mmol) and Boc20 (1.00 g, 4.58 mmol). After stirring for 20 min, a homogeneous solution had formed. The reaction was stirred another 12 hours, after which it was washed with 1 N aqueous HCl, water, dried (Na2S04) and concentrated to dryness, providing tert-butyl 5-bromo-lH-pyrazolo[3,4-c]pyridine-l- carboxylate: MS (EI) calc'd for CiiHi3BrN302 [M+H]+ 298 and 300, found 298 and 300; 1H MR (600 MHz, CDC13) delta 9.30 (s, 1 H), 8.16 (s, 1 H), 7.83 (s, 1 H), 1.71 (s, 9 H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50% | t-BuLi (27 mL, 1.7 M in pentane) was added to 100 mL of THF at -78 0C. 5-bromo-lH-pyrazolo[3,4-c]pyridine (3.0 g, 15 mmol) was added dropwise to the solution in 50 ml of THF via addition funnel. The resulting mixture was stirred for 1 h, at which point DMF (6.0 mL, 76 mmol) was added dropwise. The reaction mixture was allowed to warm to room temperature and stirred 2 h. The reaction was then carefully quenched with aq. NH4Cl and diluted with EtOAc. The resulting biphasic mixture was partitioned in a <.-- EPO <DP n="43"/>--> <img id="imgf000043_0001" he="6" wi="69" file="imgf000043_0001.tif" img-format="tif" img-content="drawing" orientation="portrait" inline="no"/> was extracted three tines with EtOAc, and the combined organic extracts were washed with brine and dried over MgSO4. Filtration and concentration under reduced pressure, followed by flash chromatography on silica gel (100% CH2Cl2 to 7.5% MeOH/ CH2Cl2), afforded the desired lH-pyrazolo[3,4- c]pyridine-5-carbaldehyde (l.lg, 50% yield) as a white solid. H1 NMR (MeOD, 400 MHz) keto tautomer: 10.17 (s, IH), 9.19 (s, IH)5 8.56 (s, IH), 8.46 (s, IH); eaol tautomer: 9.00 (s, IH), 8.25 (s, IH), 8.05 (s, 2H), 5.73 (s, IH). MS (API-ES) m/z (%): 147 (100%, M++l). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Triethylaluminum (21.7 mL, 40.4 mmol, 25 wt% solution in toluene) was added to a vigorously stirred solution of 5-bromo-1 H-pyrazolo[3,4-c]pyridine [929617-35-6] (4.00 g, 20.2 mmol) and Pd(PPh3)4 (1.17 g, 1.01 mmol) in THF (100 mL) under argon. The reaction mixture was stirred at 65C for 60 h. The mixture was cooled to RT and poured into sat. aq. NH4CI. The resulting suspension was filtered, the solid was washed with water and discarded. The filtrate and combined washings were extracted with EtOAc (3x). The combined organic extracts were washed with brine, then dried (Phase separator) and concentrated under reduced pressure. The residual oil was purified by flash column chromatography on silica gel (EtOAc/c-hexane 50:50, then 75:25, then 100:0). TLC, Rf (c-hexane/EtOAc 1 :3) = 0.22; MS (LC-MS): 148 [M+H]+, tR (HPLC conditions k): 0.71 min. | ||
With tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; toluene; at 65℃; for 60h;Inert atmosphere; | 5-Ethyl-I H-pyrazolo[3,4-c]pyridi neTriethylaluminum (21 .7 mL, 40.4 mmol; 25 wt% solution in toluene) was added to a vigorouslystirred solution of <strong>[929617-35-6]5-bromo-1H-pyrazolo[3,4-c]pyridine</strong> [929617-35-6] (4.00 g, 20.2 mmol) andPd(PPh3)4 (1.17 g, 1.01 mmol) in THF (100 mL) under argon. The reaction mixture was stirred at65C for 60 h, cooled to RT and poured into sat. aq. NH4CI. The resulting suspension wasfiltered, the solid was washed with water and discarded. The filtrate and combined washings were extracted with EtOAc (3x). The combined organic extracts were washed with brine, then dried (phase separator), concentrated and purified by flash column chromatography on silica gel (c-hexaneEtOAc gradient 5:5 to 0:10) to give the title compound. TLC, R (c-hexaneEtOAc 1:3) = 0.22; MS (LCMS): 148 [M+H]+, tR (HPLC conditions b): 0.71 mm. | |
With triphenylphosphine; In tetrahydrofuran; at 65℃; for 60h;Inert atmosphere; | 5-Ethyl-I H-pyrazolo[3,4-c]pyridi neTriethylaluminum (21 .7 mL, 40.4 mmol, 25 wt% solution in toluene) was added to a vigorously stirred solution of 5-bromo-IH-pyrazolo[3,4-c]pyridine [929617-35-6] (4.00 g, 20.2 mmol) and Pd(PPh3)4 (1.17 g, 1.01 mmol) in THF (100 mL) under argon. The reaction mixture was stirred at 65C for 60 h, cooled to RT and poured into sat. aq. NH4CI. The resulting suspension was filtered, the solid was washed with water and discarded. The filtrate and combined washings were extracted with EtOAc (3x). The combined organic extracts were washed with brine, then dried (phase separator), concentrated and purified by flash column chromatography on silica gel (c-hexane/EtOAc 5:5 to 0:10) to give the desired material. TLC, R1 (c-hexane/EtOAc 1:3) = 0.22; MS (LC/MS): 148 [M+H]+, tR (HPLC conditions d): 0.71 mm. |
With tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; toluene; at 65℃; for 60h;Inert atmosphere; | Triethylaluminum (21 .7 mL, 40.4 mmol, 25 wt% solution in toluene) was added to a vigorously stirred solution of 5-bromo-1 H-pyrazolo[3,4-c]pyridine [929617-35-6] (4.00 g, 20.2 mmol) and Pd(PPh3)4 (1.17 g, 1.01 mmol) in THF (100 mL) under argon. The reaction mixture was stirred at 65C for 60 h. The mixture was cooled to RT and poured into sat. aq. NH4CI. The resulting suspension was filtered, the solid was washed with water and discarded. The filtrate and combined washings were extracted with EtOAc (3x). The combined organic extracts were washed with brine, dried (Phase separator) and concentrated under reduced pressure. The residual oil was purified by flash column chromatography on silica gel (EtOAc/c-hexane 50:50, then 75:25, then 100:0) to give the title compound. TLC, Rf (c-hexane/EtOAc 1 :3) = 0.22; MS (LC-MS): 148 [M+H]+; tR (HPLC conditions d): 0.71 min. | |
With tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; toluene; at 65℃; for 60h;Inert atmosphere; | Triethylaluminum (21 .7 mL, 40.4 mmol, 25 wt% solution in toluene) was added to a vigorouslystirred solution of 5-bromo-i H-pyrazolo[3,4-c]pyridine [929617-35-6] (4.00 g, 20.2 mmol) andPd(PPh3)4 (1.17 g, 1.01 mmol) in THF (100 mL) under argon. The reaction mixture was stirred at 65C for 60 h, cooled to RT and poured into sat. aq. NH4CI solution. The resulting suspension was filtered, the solid was washed with water and discarded. The filtrate and combined washings were extracted with EtOAc (3x). The combined organic extracts were washed with brine, then dried (phase separator), concentrated and the product purified by flash column chromatography on silica gel (EtOAc/c-hexane 5/5 to 10/0). TLC, R (c-hexane/EtOAc 1:3) = 0.22; MS (LC/MS): 148 [M+H]+, tR (H PLC conditions d): 0.71 mm. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-iodo-succinimide; In N,N-dimethyl-formamide; at 20℃; | A solution containing 5-bromo-lH-pyrazolo[3,4-c]pyridine (168.0 g, 848.4 mmol) and NIS (286.3 g, 1.27 mol) in DMF (1.2 L) was stirred on at room temperature. The reaction mixture was poured into water then filtered. The solid was washed with water and 5% Na2S205. The crude product was dried under high vacuum overnight to give 5-bromo-3-iodo-lH- pyrazolo[3,4-c]pyridine. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
8 mg | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,2-dimethoxyethane; water; at 95℃; for 10h;Inert atmosphere; | To a solution of (R)-5-(2-hydroxy-l-phenylethyl)-amino)-pyridin-3-yl)-boronic acid (149 mg, 0.75 mmol) in DME/H20 (5: 1, 6 mL) was added Pd(PPh3)4 (173 mg, 0.15 mmol), K2C03 (207 mg, 1.5 mmol) and 5-bromo-lH-pyrazolo[3,4-c]pyridine (193.5 mg, 0.75 mmol). The resulting mixture was degassed and then stirred for 10 hours at 95 C under an Ar atmosphere. After cooling, the mixture was diluted with water (30 mL) and then extracted with EtOAc (2 x 50 mL). The combined organic layers were washed with water and brine, and then dried. The solvent was concentrated and the residue was purified by Prep-HPLC to give (R)-2-phenyl-2-[5- (lH-pyrazolo[3,4-c]pyridin-5-yl)-pyridin-3-ylamino]-ethanol (8 mg). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
36% | With caesium carbonate; In N,N-dimethyl-formamide; at 80℃; for 3.5h; | To a solutionof 28(7.80 g, 39.4 mmol) in N,N-dimethylformamide (DMF) (120 ml) were added tert-butyl4-[(methanesulfonyl)oxy]piperidine-1-carboxylate (16.5 g, 58.0 mmol) and Cs2CO3(25.7 g, 78.9 mmol). The mixture was stirred at 80 C for 3.5 h. The reaction mixture was concentrated and purified by silica gel column chromatography(0-80% EtOAc in hexanes) to afford 29as a yellow solid (5.38 g, 36% yield).1H NMR (300 MHz, CDCl3): delta ppm1.50 (s, 9 H), 1.96 - 2.13 (m, 2 H), 2.14 - 2.34 (m, 2 H), 2.87 - 3.09 (m, 2 H),4.19 - 4.47 (m, 2 H), 4.56 - 4.73 (m, 1 H), 7.78 - 7.85 (m, 1 H), 8.00 (s, 1 H),8.77 (s, 1 H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; at 25℃; for 12h; | To a solution of 5-bromo-1H-pyrazolo[3,4-cjpyndine (XVI) (200 g, 1.01 mol, 1.00 eq) in DCM (1.60 L), THF (1.60 L) and DMF (100 mL) at 25C was added 3,4-dihydro-2H- pyran (169 g, 2.02 mol, 2.00 eq) and p-TsOH (17.4 g, 101 mmol, 0.10 eq). The reaction solution was stirred at 25C for 12 h. The solvent was removed under vacuum. 10% NaHCO3 (2 L) and EtOAc (2 L) was added to the residue. The layers were separated and the organic layer washed with brine (500 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure to give 5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-cjpyndine (XVII) (280 g, cmde) as yellow solid. The cmde product was used for the next step without any purification. ESIMS found for C,,H,2BrN3O mlz 283.9 (M+H). | |
With toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; at 25℃; for 12h; | Step 3 [0612] To a solution of 5-bromo-lH-pyrazolo[3,4-c]pyridine (XVI) (200 g, 1.01 mol, 1.00 eq) in DCM (1.60 L), THF (1.60 L) and DMF ( 100 mL) at 25C was added 3,4- dihydro-2H-pyran (169 g, 2.02 mol, 2.00 eq) and p-TsOH (17.4 g, 101 mmol, 0.10 eq). The reaction solution was stirred at 25C for 12 h. The solvent was removed under vacuum. 10% NaHC03 (2 L) and EtOAc (2 L) was added to the residue. The layers were separated and the organic layer washed with brine (500 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure to give 5-bromo-l-(tetrahydro-2H-pyran-2-yl)-lH-pyrazolo[3,4- c]pyridine (XVII) (280 g, crude) as yellow solid. The crude product was used for the next step without any purification. ESIMS found for CnHi2BrN30 mlz 283.9 (M+H). | |
With toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; at 25℃; for 12h; | Step 3 [0613] To a solution of 5-bromo-lH-pyrazolo[3,4-c]pyridine (XVI) (200 g, 1.01 mol, 1.00 eq) in DCM (1.60 L), THF (1.60 L) and DMF (100 mL) at 25C was added 3,4- dihydro-2H-pyran (169 g, 2.02 mol, 2.00 eq) and p-TsOH (17.4 g, 101 mmol, 0.10 eq). The reaction solution was stirred at 25C for 12 h. The solvent was removed under vacuum. 10% NaHCC (2 L) and EtOAc (2 L) was added to the residue. The layers were separated and the organic layer washed with brine (500 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure to give 5-bromo-l-(tetrahydro-2H-pyran-2-yl)-lH-pyrazolo[3,4- c]pyridine (XVII) (280 g, crude) as yellow solid. The crude product was used for the next step without any purification. ESIMS found for CnHi2BrN30 mlz 283.9 (M+H). |
With toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; at 25℃; for 12h; | To a solution of 5-bromo-1H-pyrazolo[3,4-cjpyndine (XVI) (200 g, 1.01 mol, 1.00 eq) in DCM (1.60 L), THF (1.60 L) and DMF (100 mL) at 25C was added 3,4-dihydro-2H- pyran (169 g, 2.02 mol, 2.00 eq) and p-TsOH (17.4 g, 101 mmol, 0.10 eq). The reaction solution was stirred at 25C for 12 h. The solvent was removed under vacuum. 10% NaHCO3 (2 L) and EtOAc (2 L) was added to the residue. The layers were separated and the organic layer washed with brine (500 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure to give 5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-cjpyridine (XVII) (280 g, cmde) as yellow solid. The cmde product was used for the next step without any purification. ESIMS found for C,,H,2BrN3O mlz 283.9 (M+H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20℃; for 1h; | NaH in mineral oil (510 mg, 13 mmol) was slowly added at 0 C. to a solution of <strong>[929617-35-6]5-bromo-1H-pyrazolo[3,4-c]pyridine</strong> (Astatech, 2.1 g, 11 mmol) and [beta-(trimethylsilyl)ethoxy]methyl chloride (2.30 mL, 13 mmol) in tetrahydrofuran (25 mL). After stirring at r.t. for 1 h, the reaction mixture was quenched with water and extracted with ethyl acetate. The organic phase was washed with brine and dried over sodium sulfate. The solvents were evaporated under reduced pressure, and the obtained crude product was purified by Biotage Isolera (2.5 g, 70%). LCMS calculated for C12H19BrN3OSi (M+H) m/z=328.1; found 328.1. |
Tags: 929617-35-6 synthesis path| 929617-35-6 SDS| 929617-35-6 COA| 929617-35-6 purity| 929617-35-6 application| 929617-35-6 NMR| 929617-35-6 COA| 929617-35-6 structure
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P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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