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Chemical Structure| 925677-91-4 Chemical Structure| 925677-91-4

Structure of 925677-91-4

Chemical Structure| 925677-91-4

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Product Details of [ 925677-91-4 ]

CAS No. :925677-91-4
Formula : C8H7N3O
M.W : 161.16
SMILES Code : NC1=NC(C2=CC=CO2)=CN=C1
MDL No. :MFCD12033106

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Application In Synthesis of [ 925677-91-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 925677-91-4 ]

[ 925677-91-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13331-23-2 ]
  • [ 33332-28-4 ]
  • [ 925677-91-4 ]
YieldReaction ConditionsOperation in experiment
80% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In ethanol; water; toluene; at 100℃; for 18h;Inert atmosphere; To a solution of 6-chloropyrazin-2-amine (1.00 g, 7.75 mmol, 1 eq.) in a solution of toluene and ethanol (20 mL, 1:1) was added furan-2-ylboronic acid (0.955 g, 8.52 mmol, 1.1 eq.), Na2CO3 (1.479 g, 13.95 mmol, 1.8 eq.) in H2O (10 mL), Pd(PPh3)4 (0.223 g, 0.193 mmol, 0.025 eq.). The reaction mixture was deoxygenated using N2 atmosphere and the reaction mixture was heated at 100° C. for 18 h. The reaction was monitored by NMR. The reaction mixture was filtered through Celite with wash of ethyl acetate (2*20 mL). The reaction mixture was diluted with water (50 mL) and extracted using ethyl acetate (2*50 mL). The separated organic layer was dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by CombiFlash on silica gel to afford 1.00 g (80percent) of 6-(furan-2-yl)pyrazin-2-amine.
 

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