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Chemical Structure| 916213-93-9 Chemical Structure| 916213-93-9
Chemical Structure| 916213-93-9

tert-Butyl 3-cyanobenzylcarbamate

CAS No.: 916213-93-9

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Cat. No.: A725925 Purity: 95%

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Product Details of [ 916213-93-9 ]

CAS No. :916213-93-9
Formula : C13H16N2O2
M.W : 232.28
SMILES Code : O=C(OC(C)(C)C)NCC1=CC=CC(C#N)=C1
MDL No. :MFCD14635695

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Application In Synthesis of [ 916213-93-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 916213-93-9 ]

[ 916213-93-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 557-21-1 ]
  • [ 171663-13-1 ]
  • [ 916213-93-9 ]
YieldReaction ConditionsOperation in experiment
70% To the Boc compound <strong>[171663-13-1]tert-butyl 3-bromobenzylcarbamate</strong> (1.8 g, 6.3 mmol) in DMF (20 ml), Zn(CN)2 (443 mg, 3.8 mmol) was added followed by the Pd(PPh3)4 and heated at 1100C for 2.5h. Then the reaction mixture was diluted with ether, washed with ammonium <n="119"/>hydroxide solution, water and brine. Crude residue was column chromatographed (20%ethylacetate/Hexanes) to yield tert-butyl 3-cyanobenzylcarbamate in 70% yield.
 

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