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Chemical Structure| 911388-92-6 Chemical Structure| 911388-92-6

Structure of 911388-92-6

Chemical Structure| 911388-92-6

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Product Details of [ 911388-92-6 ]

CAS No. :911388-92-6
Formula : C8H12N2O2
M.W : 168.19
SMILES Code : OC1=NC(COC)=NC(CC)=C1
MDL No. :MFCD20491935

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Application In Synthesis of [ 911388-92-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 911388-92-6 ]

[ 911388-92-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 30414-53-0 ]
  • [ 1903-91-9 ]
  • [ 911388-92-6 ]
YieldReaction ConditionsOperation in experiment
Preparation of 2-methoxymethyl-4-hydroxy-6-ethylpyrimidine; 116 ml of a 30% strength sodium methoxide solution are diluted with 100 ml of methanol and, with ice-cooling, a solution of 26 g (208.7 mmol) of methoxy-acetamidinium hydrochloride in 200 ml of methanol is added dropwise. After the dropwise addition, the mixture is stirred for 1 h, and a solution of 27.1 g (208.7 mmol) of methyl propionyl acetate in 100 ml of methanol is then added dropwise at RT. The reaction mixture is stirred at RT for 96 h. For work-up, the reaction mixture is concentrated, the residue is taken up in 100 ml of H2O and the aqueous mixture is adjusted to pH 6 using concentrated HCl. The mixture is then concentrated and the residue is taken up in 30 ml of methanol. The solid is filtered off with suction, and concentration of the mother liquor gives 38.5 g of product. 1H-NMR: delta [CDCl3] 1.20 (t, 3H), 2.50 (q, 2H), 3.42 (s, 3H), 4.35 (s, 2H), 6.04 (s, 1H).
 

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