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Chemical Structure| 908600-92-0 Chemical Structure| 908600-92-0

Structure of 908600-92-0

Chemical Structure| 908600-92-0

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Product Details of [ 908600-92-0 ]

CAS No. :908600-92-0
Formula : C11H13FINO2
M.W : 337.13
SMILES Code : O=C(NC1=C(C=CC=C1F)I)OC(C)(C)C
MDL No. :MFCD27976476

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Application In Synthesis of [ 908600-92-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 908600-92-0 ]

[ 908600-92-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 98968-72-0 ]
  • [ 908600-92-0 ]
YieldReaction ConditionsOperation in experiment
65% Step A: (2-fluoro-6-iodo-phenyl)-carbamic acid terf-butyl esterTo a cooled (-78 C) solution of (2-fluoro-phenyl)-carbamic acid ferf-butyl ester (38.0 g, 180 mmol) in THF (700 mL) under nitrogen was added ferf-butyllithium (1.7 M, 240 mL, 408 mmol). The mixture was stirred for 1 h at -78 C and then a solution of iodine (60.8 g, 240 mmol) in THF (150 mL) was added slowly. The reaction mixture was stirred for further 1 h. Saturated aqueous ammonium chloride (100 mL) was added slowly and the mixture was warmed to RT. The layers were separated and the aqueous layer was extracted with ethyl acetate (2 x 100 mL). The combined organic fractions were washed with brine (200 mL), dried over anhydrous sodium sulfate, and concentrated. The residue was purified by flash chromatography (5% ethyl acetate:hexanes) to afford 39.1 g (65%) of the title compound as a while solid. 1 H NMR (300 MHz, CDCI3): δ 1 .50 (s, 9H), 5.98 (br. s, 1 H), 6.92 - 6.99 (m, 1 H), 7.08 - 7.15 (m, 1 H), 7.62 (dt, J=7.8, 1.2 Hz, 1 H).
 

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