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Chemical Structure| 908355-82-8 Chemical Structure| 908355-82-8

Structure of 908355-82-8

Chemical Structure| 908355-82-8

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Product Details of [ 908355-82-8 ]

CAS No. :908355-82-8
Formula : C8H7NOS2
M.W : 197.28
SMILES Code : SC1=NC2=CC=CC(OC)=C2S1

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Application In Synthesis of [ 908355-82-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 908355-82-8 ]

[ 908355-82-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 75-15-0 ]
  • [ 3970-39-6 ]
  • [ 908355-82-8 ]
  • 2
  • [ 112970-44-2 ]
  • [ 140-89-6 ]
  • [ 908355-82-8 ]
YieldReaction ConditionsOperation in experiment
98% In N,N-dimethyl-formamide; at 135℃; for 6h;Inert atmosphere; A solution of Intermediate iSA (3.25 g, 16.09 mmol) and potassium 0-ethyl carbonodithioate (6.45 g, 40.2 mmol) in DMF (20 mL) was heated at 135 C under argon for 6.0 h. HPLC and LCMS indicated a completion of the reaction. The mixture was cooled to room temperature, diluted with 20 mL water, followed by addition of 30 mL 1.0 N HC1. The precipitate formed was collected by filtration, washed with water, dried under vacuum and then chased with toluene (3X) to yield Intermediate 15B (3.1 g, 15.71 mmol, 98 % yield) as a brown solid. It was used for the next step without further purification. ?H NMR (500MHz, DMSO-d6) 13.77 (br. s., 1H), 7.38 (t, J=8.1 Hz, 1H), 6.94 (t, J=8.1 Hz, 2H), 3.91 (s, 3H); LC-MS: method A, RT = 1.63 mm, MS (ESI) m/z:198.0(M+H).
 

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