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Chemical Structure| 89638-21-1 Chemical Structure| 89638-21-1

Structure of 89638-21-1

Chemical Structure| 89638-21-1

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Product Details of [ 89638-21-1 ]

CAS No. :89638-21-1
Formula : C9H7FO
M.W : 150.15
SMILES Code : C=CC(C1=CC=CC=C1F)=O
MDL No. :MFCD02259873

Safety of [ 89638-21-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H315-H318-H335-H227
Precautionary Statements:P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P332+P313-P362-P370+P378-P403+P233-P403+P235-P405-P501

Application In Synthesis of [ 89638-21-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 89638-21-1 ]

[ 89638-21-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 198967-24-7 ]
  • [ 1826-67-1 ]
  • [ 89638-21-1 ]
YieldReaction ConditionsOperation in experiment
58.4% In tetrahydrofuran; at -78 - 20℃; A solution of <strong>[198967-24-7]2-fluoro-N-methoxy-N-methylbenzamide</strong> (16 g, 87.4 mmol) in THF (150 mL) was cooled to -78 C. Vinylmagnesium bromide (120 mL, 120 mmol) was slowly added, and the mixture stirred at -78 C. for 10 min, slowly warmed to rt, and stirred for another 3 h. The reaction mixture was quenched with 1 N aq HCl (100 mL) at 0 C. The aqueous layer was extracted with EtOAc (100 mL). The combined organic phase was washed with brine (50 mL), dried over Na2SO4, and concentrated. The residue was purified by column chromatography to afford 1-(2-fluorophenyl)-prop-2-en-1-one (7.6 g, yield: 58.4%) as a colorless oil.
 

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