Home Cart Sign in  
Chemical Structure| 886500-21-6 Chemical Structure| 886500-21-6

Structure of 886500-21-6

Chemical Structure| 886500-21-6

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 886500-21-6 ]

CAS No. :886500-21-6
Formula : C8H6ClF3O
M.W : 210.58
SMILES Code : OCC1=C(C(F)(F)F)C=CC=C1Cl
MDL No. :MFCD00049315

Safety of [ 886500-21-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Application In Synthesis of [ 886500-21-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 886500-21-6 ]

[ 886500-21-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2376-00-3 ]
  • [ 886500-21-6 ]
YieldReaction ConditionsOperation in experiment
6.23 g With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 60℃; for 92h;Inert atmosphere; Borane-methyl sulfide complex (44.6 mL, 89.2 mmol, 2.0 M) was added dropwise to the solution of <strong>[2376-00-3]2-chloro-6-(trifluoromethyl)benzoic acid</strong> (5.0 g, 22.3 mmol) at 0 C under argon atmosphere. The resulting mixture was stirred at 60 C for 27 h. LCMS indicated the reactant was remained. Then, borane-methyl sulfide complex (33.5 mL, 66.9 mmol, 2.0 M) was added dropwise at 0 C. The resulting mixture was reacted at 60 C for 65 h. After cooling to room temperature, the reaction mixture was adjusted to about pH = 11 with 2.0 M sodium hydroxide solution, diluted with water (200 mL), extracted with diethyl ether (100 mL × 3). The combined organic layers were washed with brine (100 mL × 2), dried over sodium sulfate, filtered and concentrated under reduced pressure to afford the product (2-chloro-6-(trifluoromethyl)phenyl)methanol as a brown solid (6.23 g). LCMS: LC retention time 1.89 min. MS (ESI) m/z 193 [M-17]+.
 

Historical Records

Technical Information

Categories