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Chemical Structure| 885522-00-9 Chemical Structure| 885522-00-9

Structure of 885522-00-9

Chemical Structure| 885522-00-9

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Product Details of [ 885522-00-9 ]

CAS No. :885522-00-9
Formula : C7H4ClIN2
M.W : 278.48
SMILES Code : IC1=NNC2=C1C=CC=C2Cl
MDL No. :MFCD07781602

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Application In Synthesis of [ 885522-00-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 885522-00-9 ]

[ 885522-00-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 37435-12-4 ]
  • [ 885522-00-9 ]
YieldReaction ConditionsOperation in experiment
87.8% With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 20℃; To a mixture of 7-chloro-lH-indazole (0.6 g, 3.93mmol, 1.0 eq.), KOH (0.55 g, 9.8 mmol) in DMF was added I2 (1.02g, 4.01 mmol, 1.02 eq.). The mixture was stirred at r.t. overnight, then quenched by aqueous Na2S204 solution. The mixture was extracted with EtOAc (2 x 50 mL). The combined organic layers were dried over anhydrous Na2S04 and concentrated. The resulting residue was purified by column chromatography (PE/EA =10: 1) to provide 7-chloro-3-iodo-lH-indazole (0.96 g, 87.8%).
 

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