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Chemical Structure| 885278-18-2 Chemical Structure| 885278-18-2

Structure of 885278-18-2

Chemical Structure| 885278-18-2

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Product Details of [ 885278-18-2 ]

CAS No. :885278-18-2
Formula : C6H8N2O2S
M.W : 172.21
SMILES Code : O=C(C1=NC=CS1)N(OC)C
MDL No. :MFCD06804573

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Application In Synthesis of [ 885278-18-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 885278-18-2 ]

[ 885278-18-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 14190-59-1 ]
  • [ 6638-79-5 ]
  • [ 885278-18-2 ]
YieldReaction ConditionsOperation in experiment
70% Thiazole-2-carboxylic acid (5 g, 38.7 mmol) and CDMT (7.47 g, 42.6 mmol) were suspended in THF under N2 at O0C. After 15 min NMM (11.7 g, 12.76 mL, 116 mmol) was added dropwise. The reaction mixture was stirred for 1.5 hr at RT, and then N- <n="23"/>methoxymethanamine hydrochloride was added at 0 0C. The reaction mixture was stirred over night at room temperature and was then concentrated under reduced pressure. The residue was redissolved in ethyl acetate and the solution was washed with water and brine, dried over anhydrous sodium sulfate. The residue after evaporation of solvents was purified by column chromatography eluting with 30percent EtOAc/hexanes to give 4.6 g (70percent) of the desired product as pale yellow oil.
 

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