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Chemical Structure| 885276-95-9 Chemical Structure| 885276-95-9

Structure of 885276-95-9

Chemical Structure| 885276-95-9

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Product Details of [ 885276-95-9 ]

CAS No. :885276-95-9
Formula : C9H7IN2O2
M.W : 302.07
SMILES Code : O=C(C1=CC=CN2C1=NC=C2I)OC
MDL No. :MFCD06739271

Safety of [ 885276-95-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 885276-95-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 885276-95-9 ]

[ 885276-95-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 133427-07-3 ]
  • [ 885276-95-9 ]
YieldReaction ConditionsOperation in experiment
With N-iodo-succinimide; In acetonitrile; at 20℃; for 2h; A mixture of imidazo[l,2-a]pyridine-8-carboxylic acid methyl ester (3.24 g, 18.3 mmol) and N-iodosuccinimide ( S) (4.11 g, 18.3 mmol) in acetonitrile (50 mL) is stirred at room temperature. After 2 hours, the reaction mixture is quenched with saturated aqueous Na2S2C>3 and extracted with EtOAc (3 x 100 mL). The combined organic layers are washed with water, brine, dried over Na2S04 and concentrated. The crude material is purified by silica gel chromatography eluting with 80% EtOAc in hexanes to afford 3-iodo-imidazo[l,2-a]pyridine-8-carboxylic acid methyl ester. Mp: 99-110C.
  • 2
  • [ 133427-08-4 ]
  • [ 885276-95-9 ]
 

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