Home Cart Sign in  
Chemical Structure| 885031-86-7 Chemical Structure| 885031-86-7

Structure of 885031-86-7

Chemical Structure| 885031-86-7

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 885031-86-7 ]

CAS No. :885031-86-7
Formula : C16H21N3O3
M.W : 303.36
SMILES Code : O=C1NC2=NC=CC=C2C31CCN(C(OC(C)(C)C)=O)CC3
MDL No. :MFCD17926161
InChI Key :ZEJLWODBJNBBKT-UHFFFAOYSA-N
Pubchem ID :56651733

Safety of [ 885031-86-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 885031-86-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 885031-86-7 ]

[ 885031-86-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5654-97-7 ]
  • [ 118753-70-1 ]
  • [ 885031-86-7 ]
YieldReaction ConditionsOperation in experiment
Preparation of Intermediate A A 12-L-three-neck flask equipped with an overhead stir, nitrogen inlet, a 2 -L addition funnel, and an internal temperature probe was charged with <strong>[5654-97-7]7-azaoxindole</strong> (72 g, 537 mmol) and anhydrous DME (2.5L). The solution was cooled to -60C and LiHMDS (296 g, 1771 mmol) was added as solution in DME (IL) via addition funnel over 30 minutes while the temperature was maintained at -60 to -54C. The reaction was allowed to warm up -20C and stirred for 40 <n="21"/>minutes. The mixture was cooled to -60C and a solution of N-BOC-bis(2-chloroethyl)amine (149 g, 617 mmol) in DME (0.5L) was added within 2 minutes. The resulting reaction mixture was allowed to reach room temperature over 10h, and stirred for 3 days. The reaction mixture was heated to 50C for 60h, cooled to room temperature and poured onto 10L of ice, combined with 4L of AcOEt, separated, aqueous layer washed with additional 2L of AcOEt, combined organic layers washed with brine and concentrated. Column chromatography afforded pure intermediate A as a solid. The slurry was filtered and the cake washed with hexanes affording the title compound as a white solid.
 

Historical Records

Technical Information

Categories