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Chemical Structure| 883987-74-4 Chemical Structure| 883987-74-4

Structure of 883987-74-4

Chemical Structure| 883987-74-4

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Product Details of [ 883987-74-4 ]

CAS No. :883987-74-4
Formula : C7H6FNO3
M.W : 171.13
SMILES Code : OCC1=CC([N+]([O-])=O)=CC(F)=C1
MDL No. :MFCD13185621

Safety of [ 883987-74-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 883987-74-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 883987-74-4 ]

[ 883987-74-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 110882-60-5 ]
  • [ 883987-74-4 ]
YieldReaction ConditionsOperation in experiment
100% To solution of 1.0 eq IB in dry Et2O (0.06 M) at 00C was added dropwise a solution of diisobutyllithiumalurninum hydride (1.1 eq, 1.0 M in hexanes) by syringe. The resulting solution was kept at 00C overnight. The reaction mixture was added to a mixture of ice and glacial acetic acid. The reaction mixture was then diluted with ethyl acetate, and the aqueous layer was extracted with ethyl acetate two additional times. The combined organic layers were washed twice with saturated sodium bicarbonate, and once with brine. The organic layers were then dried over sodium sulfate, filtered and concentrated in vacuo. Purification over silica gel using 10% EtOAc/hexanes as the eluant afforded a yellow solid (100%) as an 80:20 mixture of 1C:1B.
 

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