Home Cart Sign in  
Chemical Structure| 88246-12-2 Chemical Structure| 88246-12-2

Structure of 88246-12-2

Chemical Structure| 88246-12-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 88246-12-2 ]

CAS No. :88246-12-2
Formula : C5H10O4
M.W : 134.13
SMILES Code : O=C(OC)C[C@@H](O)CO

Safety of [ 88246-12-2 ]

Application In Synthesis of [ 88246-12-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 88246-12-2 ]

[ 88246-12-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 617-55-0 ]
  • [ 3068-00-6 ]
  • [ 52079-23-9 ]
  • [ 497-23-4 ]
  • [ 88246-12-2 ]
YieldReaction ConditionsOperation in experiment
With hydrogen; In Dimethyl ether; at 56 - 110℃; under 120012.0 Torr; for 0.5 - 2h;Product distribution / selectivity; HYDROGENATION OF DIMETHYL MALATE:; The following conditions were used Hydrogen pressure 0,1, 10 and 30 bar Substrate 0,4 and 1,5 mol% Catalyst CuMn AI203, particle size 90-180 um Samples are taken at regular intervals after the substrate feed is started. Experiment 1: This was performed according to the procedure described above in Materials, Equipment and Activation Procedure. The reaction temperature was 56C, Hydrogen pressure was 10bar, DME pressure was 150bar, substrate concentration in solution was 0.4 mol%, and 10G of catalyst were used. The following results were obtained: Time on DM L DE BT HGB H-THF HGB equiv Selectivity stream area% area% 5 67.5 0.22 15.16 0.14 15.86 0.1 31.02 95.4% 13 58.4 0.09 21.45 0.27 18.29 0.07 39.74 95.5% 20 63.1 0.15 19.8 0.37 15.6 0.07 35.4 95.9% 30 67.8 0.07 18.2 0.58 12.39 0.06 30.59 95.0% 60 76.5 0.04 15 0.48 7.22 0.04 22.22 94.6% DM = dimethyl malate L = 2 (5H)-Furanone DE = 3,4-dihydroxy methyl butyrate ester BT = butanetriol HGB = 3-hydroxy-gammabutyrolactone (produced by in-situ cyclisation of 3,4-dihydroxy methyl butyrate ester) H-THF = hydroxy-THF Notes: HGB EQUIVALENT = area%"HGB"+ area%"Dihydroxy ester" (as hydroxy ester can be cyclise to HGB) SELECTIVITY DEFINED AS (AREA% USEFUL PRODUCTS) / (AREA % OF ALL PRODUCTS) HGB (S) was obtained in 97.9% ee Experiment 2: This was performed according to the procedure described above in Materials, Equipment and Activation Procedure. The reaction temperature was 110C, Hydrogen pressure was 10bar, DME pressure was 150bar, substrate concentration in solution was 1.5 mol%, and 5.9g of catalyst were used. The following results were obtained : Time on DM L DE BT HGB H-THF HGB equiv Selectivity stream area% area% 5 64.1 0.55 18.22 1.6 15.3 33.52 93.4% 15 72.6 0.24 15.38 0.9 10 0.1 25.38 92.6% 30 77.6 0.16 13.3 0.5 7.8 0.1 21.1 94.2% Note: HGB (S) obtained in 98.8% ee Conclusion: These experiments illustrate high selectivity for HGB in the hydrogenation of dimethyl malate EXPERIMENT-MEOH removal and the effect on the conversion of LDMM to HGB Experiment 3: This was performed according to the procedure described above in Materials, Equipment and Activation Procedure. The reaction temperature was 80C, Hydrogen pressure was 10bar, DME pressure was 150bar, substrate concentration in solution was 0.4 mol%, and 87g of catalyst were used. After 2 hours on stream, the product was found to contain 39.8 area% starting material and 51.5 area% HGB-EQUIVALENT (as defined in Example 1). The product was formed with 85.5% selectivity. The collected product from this experiment, after depressurisation and removal of Methanol, was used as the feed for another hydrogenation, under otherwise identical conditions. The following results were obtained. Time on DM area% L DE BT HGB HGB Selectivity stream equiv area% 50 14.7 5.3 15.2 8 47.4 62.6 73.4% 60 18. 8 4.4 14. 8 11.7 45.5 60.3 74.3% 75 21.15 3.7 21.1 11.5 43.2 64. 3 81.5% 90 13. 4 7. 1 5.5 59.1 66.2 76.4% 105 26.7 3.4 17.5 8.7 40.6 58. 1 79.3% 120 25.6 2.3 17.7 9.5 42 59.7 80. 2% Conclusions : When the reaction products from one incomplete hydrogenation are depressurised and Methanol removed by evaporation, then re-hydrogenated the conversion is increased FROM-50% TO-60%, and the selectivity remains approximately constant.
 

Historical Records

Technical Information

Categories