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Chemical Structure| 881841-30-1 Chemical Structure| 881841-30-1

Structure of 881841-30-1

Chemical Structure| 881841-30-1

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Product Details of [ 881841-30-1 ]

CAS No. :881841-30-1
Formula : C8H5ClN2O
M.W : 180.59
SMILES Code : O=CC1=CN2C=C(Cl)C=CC2=N1
MDL No. :MFCD06739239

Safety of [ 881841-30-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Application In Synthesis of [ 881841-30-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 881841-30-1 ]

[ 881841-30-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1039416-36-8 ]
  • [ 881841-30-1 ]
YieldReaction ConditionsOperation in experiment
With manganese(IV) oxide; In dichloromethane; for 0.5h;Heating / reflux; Step (a) 6-chloroimidazo[l,2-a]pyridine-2-carbaldehyde; 6-Chloro-imidazo[l,2-a]pyridine-2-carboxylic acid (0.4 g, 2 mmol) was dissolved in dry THF (10 ml) and 1.0M borane/THF solution (5 ml, 5 mmol) was added, and the mixture heated at reflux for 2h. Mixture was quenched with methanol (2 ml), acidified with 3 drops of concentrated hydrochloric acid and heated at reflux for 15 min. The mixture was then adsorbed on to SCX resin, washed well with methanol and the crude alcohol intermediate eluted with 10% aqueous ammonia in methanol. This intermediate (0.4 g, 2.2 mmol) was mixed with manganese dioxide (2 g, 23 mmol) in dichloromethane (50 ml) and was heated at reflux for 30 min. The inorganics were removed by filtration and the filtrate evaporated to dryness to afford the sub-title compound (0.32 g, 89%). <n="42"/>1H NMR (300 MHz, CDCl3): delta 10.22 (s, IH), 8.33 (s, IH), 8.09 (s, IH), 7.64 (d, IH), 7.27 (dd, IH)
  • 2
  • [ 67625-38-1 ]
  • [ 881841-30-1 ]
 

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