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Structure of 87955-28-0

Chemical Structure| 87955-28-0

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Product Details of [ 87955-28-0 ]

CAS No. :87955-28-0
Formula : C11H15NO
M.W : 177.24
SMILES Code : C1(CC2=CC=CC=C2)CNCCO1
MDL No. :MFCD09055007
InChI Key :YZFCMGWCEXUGFX-UHFFFAOYSA-N
Pubchem ID :125510

Safety of [ 87955-28-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 87955-28-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 87955-28-0 ]

[ 87955-28-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 4436-24-2 ]
  • [ 926-39-6 ]
  • [ 131887-46-2 ]
  • [ 87955-28-0 ]
  • 2
  • [ 926-39-6 ]
  • [ 5396-65-6 ]
  • [ 87955-28-0 ]
YieldReaction ConditionsOperation in experiment
30% Synthesis of 2-Benzyl-morpholine [A034] To a stirred solution of NaOH (1.63 g, 40.8 mmol) in water3.5 ml) was added l-Chloro-3- phenyl-propan-2-ol [A035] (1.16 g, 6.8 mmol) in MeOH (7 ml). After 5 min 2-Aminoethane hydrogen sulphate (3.84 g, 27.2mmol) was added and the reaction mixture stirred at 40 °C for 2 hours. NaOH (powdered, 1.63g, 40.8mmol) and PhMe (18 ml) were then added and the reaction heated to 65 °C for 18 hours. Dilution with water (10 ml), was followed by extraction with PhMe (x2). The combined organics were washed (water then brine), dried and concentrated. Purification by column chromatography (0-10percent MeOH:DCM) provided the title compound as a colourless oil (360 mg, 30percent). 1H-NMR (1H, 300MHz, CDC13): 7.31- 7.19 (5H, m), 3.86 (1H, dd), 3.70-3.54 (2H, m), 2.92-2.77 (4H, m), 2.67-2.55 (2H, m).
 

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[ 87955-28-0 ]

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