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Structure of 878287-56-0

Chemical Structure| 878287-56-0

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Product Details of [ 878287-56-0 ]

CAS No. :878287-56-0
Formula : C11H7FN4
M.W : 214.20
SMILES Code : FC1=CC=CC=C1C2=NC3=CN=CN=C3N2
MDL No. :MFCD16877237
InChI Key :WSJXIFBIXREODX-UHFFFAOYSA-N
Pubchem ID :46941611

Safety of [ 878287-56-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 878287-56-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 878287-56-0 ]

[ 878287-56-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13754-19-3 ]
  • [ 445-29-4 ]
  • [ 878287-56-0 ]
YieldReaction ConditionsOperation in experiment
88.5% A mixture of <strong>[13754-19-3]4,5-diaminopyrimidine</strong> (0.500 g), 2-fluorobenzoic acid (0.700 g) and polyphosphoric acid (25 mL) was heated at 180 C. for 3 hours. Then the reaction mixture was cooled and poured into water (500 mL). The solution was adjusted to pH=8-9 by addition of solid NaOH and the resulting precipitate was collected by filtration, washed with water and dried to give 8-(2-fluorophenyl)-purine (off-white powder, 88.5%). 1H NMR (200 MHz, DMSO-d6) delta 13.79 (br s, 1H, NH), 9.14 (s, 1H, purine-H), 8.95 (s, 1H, purine-H), 8.23 (m, 1H, phenyl-H), 7.73-7.41 (m, 3H, phenyl-H).
 

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