878197-91-2|2-(Dichloromethyl)-5-fluoroimidazo[1,2-a]pyridine| Ambeed

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CAS No. :	878197-91-2
Formula :	C₈H₅Cl₂FN₂
M.W :	219.04
SMILES Code :	FC1=CC=CC2=NC(C(Cl)Cl)=CN12

Yield	Reaction Conditions	Operation in experiment
65%	In 1,2-dimethoxyethane; at 85℃; for 15h;	B) 2-(Dichloromethyl)-5-fluoroimidazoH .2-alpyridine: A solution of <strong>[1597-32-6]6-fluoro-2-pyridinamine</strong> (67 g, 0.60 mol) in ethylene glycol dimethyl ether (570 mL) was treated with 1 ,1 ,3-trichloroacetone (190 mL, 1.80 mol) and heated at 850C for 15 hours. The reaction was cooled in an ice bath and the precipitate filtered, rinsed with hexanes, and dried to yield 2-(dichloromethyl)-5-fluoroimidazo[1 ,2-a]pyridine (85 g, 65% yield) as an olive green solid. 1H-NMR (CDCI3): δ 8.18 (s, 1 H), 7.60 (s, 1 H), 7.54-7.46 (m, 2H), 6.93 (m, 1H).
65%	In 1,2-dimethoxyethane; at 85℃; for 15h;	A solution of <strong>[1597-32-6]6-fluoro-2-pyridinamine</strong> (67 g, 0.60 mol) in ethylene glycol dimethyl ether (570 mL) was treated with 1 ,1 ,3-trichloroacetone (190 mL, 1.80 mol) and heated at 850C for 15 hours. The reaction was cooled in an ice bath and the precipitate filtered, rinsed with hexanes, and dried to yield 2-(dichloromethyl)-5- fluoroimidazo[1 ,2-a]pyridine (85 g, 65% yield) as an olive green solid. 1H-NMR (CDCI3): δ 8.18 (s, 1 H), 7.60 (s, 1 H), 7.54-7.46 (m, 2H), 6.93 (m, 1 H).
65%	In 1,2-dimethoxyethane; at 85℃; for 15h;Product distribution / selectivity;	A solution of <strong>[1597-32-6]6-fluoro-2-pyridinamine</strong> (67 g, 0.60 mol) in ethylene glycol dimethyl ether (570 ml_) was treated with 1 ,1 ,3-trichloroacetone (190 mL, 1.80 mol) and heated at 850C for 15 hours. The reaction was cooled in an ice bath and the precipitate filtered, rinsed with hexanes, and dried to yield 2-(dichloromethyl)-5- fluoroimidazo[1 ,2-a]pyridine (85 g, 65% yield) as an olive green solid. 1H-NMR (CDCl3): δ 8.18 (s, 1H), 7.60 (s, 1H), 7.54-7.46 (m, 2H), 6.93 (m, 1H).

Precautionary Statements-General
Code	Phrase
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Response
Code	Phrase
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P321
P322
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P378
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P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
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P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P370 + P378	In case of fire:
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P401
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Disposal
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Physical hazards
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
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H204	Fire or projection hazard
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H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
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H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
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H271	May cause fire or explosion; strong oxidizer
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Health hazards
Code	Phrase
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H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
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H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
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H340	May cause genetic defects
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H351	Suspected of causing cancer
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H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 878197-91-2

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CAS No.: 878197-91-2

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