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Chemical Structure| 877402-84-1 Chemical Structure| 877402-84-1

Structure of 877402-84-1

Chemical Structure| 877402-84-1

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Product Details of [ 877402-84-1 ]

CAS No. :877402-84-1
Formula : C8H9BrF3N3O
M.W : 300.08
SMILES Code : O=C(C1=CC(C(F)(F)F)=NN1)NCCCBr

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Application In Synthesis of [ 877402-84-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 877402-84-1 ]

[ 877402-84-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 129768-28-1 ]
  • [ 5003-71-4 ]
  • [ 877402-84-1 ]
YieldReaction ConditionsOperation in experiment
With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20℃; for 0.75h; To a solution of 500 mg (2.78 mmol) of 3-(trifluoromethyl)-lNo.-pyrazole-5-carboxylicacid, 682 mg (3.05 mmol) of 3-brornopropylamine hydrobromide, and 1.4 mL (1.04 g, 8.04 mmol) ofAr,W-diisopropylethylamine in 20 mL of dichloromethane were added 1.2 g (3.06 mmol) of O-(7-azabenzotriazol-l-yl)-N,]V,Af',7V'-tetramethyluromumhexafluorophosphate (HATU) and 459 mg (3.38mmol) of l-hydroxy-7-azabenzotriazole (HOAT). After being stirred at room temperature for 45 min, thereaction mixture was partitioned between dichloromethane and saturated sodium carbonate aqueoussolution. The organic phase was washed with 5% aqueous citric acid solution, then dried over sodiumsulfate, and concentrated. The residue was leached with dichloromethane containing a little methanol.Concentration of the organic extract yielded the title compound. LC-MS 300, 302 (M+l).
 

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