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Chemical Structure| 874880-53-2 Chemical Structure| 874880-53-2

Structure of 874880-53-2

Chemical Structure| 874880-53-2

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Product Details of [ 874880-53-2 ]

CAS No. :874880-53-2
Formula : C8H6FNS2
M.W : 199.27
SMILES Code : CSC1=NC2=CC(F)=CC=C2S1

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Application In Synthesis of [ 874880-53-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 874880-53-2 ]

[ 874880-53-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 155559-81-2 ]
  • [ 74-88-4 ]
  • [ 874880-53-2 ]
YieldReaction ConditionsOperation in experiment
Example 40Preparation of7V,7V-dicyclopropyl-6-ethyl-4-(5-fluorobenzo[d]thiazol-2-ylamino)-l- methyl-l,6-dihydroimidazo [4,5-d] pyrrolo [2,3-b] pyridine-7-carboxamide 40A Preparation of 5-fluoro-2- methylthio)benzo|"d"lthiazole[00284] To a solution of <strong>[155559-81-2]5-fluoro-2-mercaptobenzothiazole</strong> (0.15 g, 0.810 mmol) in THF (8.10 niL) cooled to 0 C was added sodium hydride (0.036 g, 0.891 mmol). After stirring 10 min, iodomethane (0.076 mL, 1.215 mmol) was added and the reaction mixture was slowly warmed to room temperature over 2 h. The reaction was diluted with ethyl acetate and quenched with saturated aqueous sodium bicarbonate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. 5-fluoro-2-(methylthio)benzo[d]thiazole (0.178 g, 110 % yield) was isolated as a white solid. Material was used without any further purification.[00285] MS (ESI) m/z 200.0 (M+H)[00286] 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 7.68 (dd, 1H, J= 8.81, 5.04 Hz), 7.56 (dd, 1H, J= 9.57, 2.52 Hz), 7.07 (td, 1H, J= 8.81, 2.52 Hz), 2.80 (s, 3H)
 

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