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Chemical Structure| 873221-73-9 Chemical Structure| 873221-73-9

Structure of 873221-73-9

Chemical Structure| 873221-73-9

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Product Details of [ 873221-73-9 ]

CAS No. :873221-73-9
Formula : C10H12N2O4
M.W : 224.21
SMILES Code : O=C(OCC)C(CC(C1=CN(C)N=C1)=O)=O

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Application In Synthesis of [ 873221-73-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 873221-73-9 ]

[ 873221-73-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 95-92-1 ]
  • [ 37687-18-6 ]
  • [ 873221-73-9 ]
YieldReaction ConditionsOperation in experiment
79% 4) 4-(1-Methyl-1H-pyrazol-4-yl)-2,4-dioxobutanoic acid ethyl ester In an argon atmosphere and at room temperature, diethyl oxalate (17.5 mL) was added to a solution of sodium ethoxide (8.77 g) in ethanol (80 mL), and the mixture was stirred for 10 minutes at room temperature. A solution of the above <strong>[37687-18-6]1-(1-methyl-1H-pyrazol-4-yl)ethanone</strong> (8.00 g) in ethanol (80 mL) was added to the reaction mixture, and the resultant mixture was stirred for 90 minutes at room temperature. The reaction mixture was partitioned between water and diethyl ether. Saturated aqueous ammonium chloride was added to the aqueous layer, and the mixture was extracted with chloroform. The organic layer was dried over sodium sulfate anhydrate. After a filtration step, the solvent was removed under reduced pressure, to thereby give 4-(1-methyl-1H-pyrazol-4-yl)-2,4-dioxobutanoic acid ethyl ester as a solid product (11.4 g, 79%). 1H-NMR(400MHz,CDCl3)delta:1.39-1.42(3H,m), 3.98(3H,s), 4.36-4.41(2H,m), 6.69(1H,s), 7.98(2H,m). EI-MSm/z:224 (M+).
 

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