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Chemical Structure| 873221-68-2 Chemical Structure| 873221-68-2

Structure of 873221-68-2

Chemical Structure| 873221-68-2

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Product Details of [ 873221-68-2 ]

CAS No. :873221-68-2
Formula : C7H11N3O2
M.W : 169.18
SMILES Code : O=C(C1=CN(C)C=N1)N(OC)C
MDL No. :MFCD21336347

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Application In Synthesis of [ 873221-68-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 873221-68-2 ]

[ 873221-68-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6638-79-5 ]
  • [ 41716-18-1 ]
  • [ 873221-68-2 ]
YieldReaction ConditionsOperation in experiment
64% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20℃; 1) N-Methoxy-N-methyl-1-methyl-1H-imidazole-4-carboxamide 1-Methyl-1H-imidazole-4-carboxylic acid (1.26 g), N,O-dimethylhydroxylamine hydrochloride (1.17 g), 1-hydroxybenzotriazole (1.84 g), triethylamine (2.09 mL), and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (2.30 g) were dissolved in N,N-dimethylformamide (50 mL), and the solution was stirred overnight at room temperature. The reaction solvent was evaporated under reduced pressure, and ethanol was added to the residue. Insoluble matter was removed through filtration, and the solvent was evaporated under reduced pressure. The residue was purified through silica gel column chromatography (chloroform - methanol - water, lower phase), to thereby give N-methoxy-N-methyl-1-methyl-1H-imidazole-4-carboxamide as a solid product (1.08 g, 64percent). 1H-NMR(400MHz,CDCl3)delta:3.45(3H,s), 3.73(3H,s), 3.78(3H,s), 7.45(1H,s),7.54(1H,s).
 

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