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Chemical Structure| 871700-07-1 Chemical Structure| 871700-07-1

Structure of 871700-07-1

Chemical Structure| 871700-07-1

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Product Details of [ 871700-07-1 ]

CAS No. :871700-07-1
Formula : C19H14F4IN3O6S
M.W : 615.29
SMILES Code : O=S(C(F)(F)F)(OC(C(C(N1C2CC2)=O)=C3N(C4=CC=C(I)C=C4F)C1=O)=C(C)C(N3C)=O)=O

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Application In Synthesis of [ 871700-07-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 871700-07-1 ]

[ 871700-07-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 871700-24-2 ]
  • [ 358-23-6 ]
  • [ 871700-07-1 ]
YieldReaction ConditionsOperation in experiment
93% With 2,6-dimethylpyridine; In chloroform; at 0 - 20℃; for 2.5h; Under a nitrogen atmosphere, to 3-cyclopropyl-l-(2-fluoro- 4-iodophenyl)-5-hydroxy-6,8-dimethyl-1H,8H-pyrido[2,3- d] pyrimidine-2,4,7-trione 55 (33.0 g) obtained in Step 5 were added chloroform (165 ml) and 2,6-lutidine(10.4 ml), and trifluoromethanesulfonic anhydride 56 (14.4 ml) was added dropwise under ice-cooling with stirring. After the completion of the dropwise addition, the mixture was stirred at same temperature for 30 min and at room temperature for 2 hrs. The reaction mixture was washed successively with aqueous sodium hydrogen carbonate (165 ml), 1N hydrochloric acid (165 ml) and brine (165 ml) and dried over anhydrous magnesium sulfate. Anhydrous magnesium sulfate was filtered off and the filtrate was concentrated under reduced pressure. 2-Propanol (198 ml) was added to the residue, and the mixture was stirred with heating under reflux, and allowed to return to room temperature. The crystals were collected by filtration and dried to give trifluoromethanesulfonic acid 3-cyclopropyl-l-(2-fluoro-4- iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydro- pyrido [2,3-d]pyrimidin-5-yl ester 43 (31.9 g, yield 93%) as colorless crystals.
 

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