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Chemical Structure| 869558-91-8 Chemical Structure| 869558-91-8
Chemical Structure| 869558-91-8

1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbaldehyde

CAS No.: 869558-91-8

4.5 *For Research Use Only !

Cat. No.: A729239 Purity: 95%

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Product Details of [ 869558-91-8 ]

CAS No. :869558-91-8
Formula : C10H18N2O2Si
M.W : 226.35
SMILES Code : O=CC1=CN(COCC[Si](C)(C)C)N=C1
MDL No. :MFCD30531240

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Application In Synthesis of [ 869558-91-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 869558-91-8 ]

[ 869558-91-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 76513-69-4 ]
  • [ 35344-95-7 ]
  • [ 869558-91-8 ]
YieldReaction ConditionsOperation in experiment
57% With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20℃; for 1h; To a stirring solution of ?H-<strong>[35344-95-7]pyrazole-4-carbaldehyde</strong> SM1 (500 mg, 5.2mmol) in DMF (lOmL) was added NaH (248mg, 6.2mmol), followed by SEMC1 (1.03g,6.2mmol) at 0 °C and stirred at room temperature for ?H. The reaction mixture was diluted with water and extracted with EA. Combined organic extracts were dried over anhydrous Na2SO4 and concentrated under reduced pressure to obtain crude product, which was purified by silica gel column chromatography to afford compound 1 (800mg,57percent). TLC:20percent EtOAc/Hexane (Rf: 0.5). LC-MS: m/z = 227[(M+1)].
 

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