[ CAS No. 868406-81-9 ] 2-Bromo-5-chloro-4-(trifluoromethoxy)aniline

Cat. No.: A172494

2D 3D

Structure of 868406-81-9

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COA NMR CNMR HPLC LC-MS

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Specification

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Product Details of [ 868406-81-9 ]

CAS No. :	868406-81-9	MDL No. :	MFCD28734569
Formula :	C₇H₄BrClF₃NO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	290.47	Pubchem ID :	-
Synonyms :

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Application In Synthesis of [ 868406-81-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 868406-81-9 ]

[ 868406-81-9 ] Synthesis Path-Downstream 1~1

1
[ 64628-73-5 ]
[ 868406-81-9 ]

Yield	Reaction Conditions	Operation in experiment
42%	With N-Bromosuccinimide; In dichloromethane; at 20℃; for 0.416667h;	Example 35: (5-Chloro-2-f(E)-3-f3-(4-fluoro-benzvl)-3,8-diaza-bicvdoo3.2.11oct-8-yll-3-oxo- propenvll-4-trifluoromethoxv-phenyl)-urea; a) 2-Bromo-5-chloro-4-trifluoromethoxy-phenylamine; N-Bromosuccinimid (7.9 g; 44.5 mmol) in CH2CI2 (500 ml) is added under stirring within 5 min. to a solution of <strong>[64628-73-5]3-chloro-4-trifluoromethoxy-phenylamine</strong> (9.4 g; 44.5 mmol) in CH2CI2 (100 ml) at room temp. After 20 min. the reaction mixture is concentrated to a volume of -150 ml, and hexanes (1000 ml) added to the precipitated crystals. The crystals are filtered off an purified via chromatography (Si02; TBME/hexanes 1/9 to 2/8) to deliver the target compound as yellowish crystals (8.4 g; 42 %). 1 H-NMR (400MHz; DMSO-d6), 8 (ppm) : 5.81 (s, 1 H); 6.94 (s, 1 H); 7.55 (s, 2H). MS (m/z) ES-: 290 (MH-).

Reference： [1]Patent: WO2005/103054,2005,A2 .Location in patent: Page/Page column 64

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Technical Information

• Alkyl Halide Occurrence • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Leuckart-Wallach Reaction • Mannich Reaction • Nomenclature of Ethers • Petasis Reaction • Preparation of Alkylbenzene • Preparation of Amines • Preparation of Ethers • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Dihalides • Reactions of Ethers • Specialized Acylation Reagents-Vilsmeier Reagent • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Ugi Reaction • Vilsmeier-Haack Reaction

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Application In Synthesis of [ 868406-81-9 ]

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[ CAS No. 868406-81-9 ] 2-Bromo-5-chloro-4-(trifluoromethoxy)aniline

Quality Control of [ 868406-81-9 ]

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[ 868406-81-9 ] Synthesis Path-Downstream 1~1

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