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Chemical Structure| 866632-57-7 Chemical Structure| 866632-57-7

Structure of 866632-57-7

Chemical Structure| 866632-57-7

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Product Details of [ 866632-57-7 ]

CAS No. :866632-57-7
Formula : C7H3F4IO
M.W : 306.00
SMILES Code : FC(F)(F)OC1=C(I)C(F)=CC=C1
MDL No. :MFCD2338250

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Application In Synthesis of [ 866632-57-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 866632-57-7 ]

[ 866632-57-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1077-01-6 ]
  • [ 866632-57-7 ]
YieldReaction ConditionsOperation in experiment
To the solution of 3- (trifluoromethoxy)fluorobenzen(1g, 5.5 mmol) in lOmL THF at -78C, n-BuLi (1.6M, 3.75mL) was added dropwise. The resulting solution was stirred at -78C for 30 min. 12 (2.1g, 8.25 mmol) in THF (5mL) was added. The mixture was warmed to room temperature and then quenched with Na2C03 in saturated Na2S203 (1: 10) (30mL). The crude product was extracted with ether. The ether layer was dried over Na2S04 and filtered through a short silica gel column to give the desired iodide as an oil. ¹H NMR (CDC13): 7.39 (m, 1H), 7.12 (d, J=9.0 Hz, 1H), 7.05 (t, J=6.0 Hz, 1H) MS (ESI): m/e 307 (M+1)+
 

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