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Chemical Structure| 865660-32-8 Chemical Structure| 865660-32-8

Structure of 865660-32-8

Chemical Structure| 865660-32-8

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Product Details of [ 865660-32-8 ]

CAS No. :865660-32-8
Formula : C12H18ClNO3
M.W : 259.73
SMILES Code : COC(OC)CNCC1=CC=C(OC)C(Cl)=C1
MDL No. :MFCD04125328

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Application In Synthesis of [ 865660-32-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 865660-32-8 ]

[ 865660-32-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 4903-09-7 ]
  • [ 865660-32-8 ]
  • 2
  • [ 4903-09-7 ]
  • [ 22483-09-6 ]
  • [ 865660-32-8 ]
YieldReaction ConditionsOperation in experiment
With sodium tris(acetoxy)borohydride; In methanol; at 0 - 20℃; General procedure: Benzaldehyde derivatives (1500 mg, 13.13 mmol) and Aminoacetaldehyde dimethyl acetal (19.70 mmol) were dissolved in 15 mL of methanol, NaBH(OAc)3 (19.70 mmol) was added at 0 C slowly in 3h. The reaction mixture was stirred at room temperature overnight and concentrated under reduced pressure. The residue was extracted with dicloromethane (DCM, 15 mL) three times, and the combined extracts were washed with 2N KOH, brine and dried over Na2SO4. The solution was filtered and added TEA (39.40 mmol) and TsCl (21.00 mmol) at 0C and stirred at room temperature for 5h. The resulting mixture was extracted with DCM (15 mL) three times. The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel flash column chromatography (PE : EA = 5:1) to give the desired product.
 

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