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Chemical Structure| 863605-35-0 Chemical Structure| 863605-35-0

Structure of 863605-35-0

Chemical Structure| 863605-35-0

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Product Details of [ 863605-35-0 ]

CAS No. :863605-35-0
Formula : C10H9FN2
M.W : 176.19
SMILES Code : CN1N=C(C2=CC=C(F)C=C2)C=C1

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Application In Synthesis of [ 863605-35-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 863605-35-0 ]

[ 863605-35-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 154258-82-9 ]
  • [ 74-88-4 ]
  • [ 863605-35-0 ]
YieldReaction ConditionsOperation in experiment
29% 3-(4-Fluorophenyl)-1-methyl-1H-pyrazole; Treat a solution of <strong>[154258-82-9]3-(4-fluorophenyl)pyrazole</strong> (7. 17 g, 44. 2 mmol) in dry DMF (60 mL) with NaH (2. 2 g, 92. 8 mmol) at 0 C for 15 min. Add iodomethane (3. 3 mL, 53. 04 mmol) and slowly warm to RT. Quench the reaction mixture with methanol (5 mL) and dilute with water (100 mL). Extract with EtOAc (3 x 70 mL), dry (MgS04) and concentrate and purify (Biotage system elueting with dichloromethane : methanol 50 : 1) to give desired compound as a white solid (2. 3 g, 29% yield). MS (ESi+) : 177 (M+H) +.
 

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