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Chemical Structure| 86-59-9 Chemical Structure| 86-59-9
Chemical Structure| 86-59-9

8-Quinolinecarboxylic acid

CAS No.: 86-59-9

8-Quinolinecarboxylic acid exhibits antibacterial, antiviral, and anticancer activities, inhibiting the growth of pathogenic microorganisms and interfering with the cell division process.

Synonyms: Quinoline-8-carboxylic acid

4.5 *For Research Use Only !

Cat. No.: A248196 Purity: 98%

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Product Details of 8-Quinolinecarboxylic acid

CAS No. :86-59-9
Formula : C10H7NO2
M.W : 173.17
SMILES Code : O=C(C1=C2N=CC=CC2=CC=C1)O
Synonyms :
Quinoline-8-carboxylic acid
MDL No. :MFCD00047619
InChI Key :QRDZFPUVLYEQTA-UHFFFAOYSA-N
Pubchem ID :66582

Safety of 8-Quinolinecarboxylic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 8-Quinolinecarboxylic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 86-59-9 ]

[ 86-59-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 86-59-9 ]
  • [ 162167-97-7 ]
  • 3-[(quinoline-8-carbonyl)-amino]-methyl}-piperidine-1-carboxylic acid <i>tert</i>-butyl ester [ No CAS ]
  • 2
  • [ 6154-04-7 ]
  • [ 86-59-9 ]
  • [ 530-62-1 ]
  • 8-(2-methyl-1H-tetrazol-5-ylcarbamoyl)quinoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
With trifluoroacetic acid; In water; N,N-dimethyl-formamide; Using the method of Example 12 the following compounds of the invention are prepared from the starting quinolines listed in the table. example 11 to a solution of 1.7 g. (10 mmole) of 8-quinoline carboxylic acid in 50 ml. of N,N-dimethylformamide is added 1.6 g. (10 mmole) of carbonyl diimidazole, and the mixture is stirred for four hours at 100 C. The reactive intermediate which is formed is reacted with 1.0 g. (10 mmole) of 5-amino-2-methyltetrazole. The reaction is carried out by adding the solution and two drops of trifluoroacetic acid to the stirred solution of reactive intermediate and heating for four hours at 140-150 C. The solution is then evaporated to remove the N,N-dimethylformamide. Water is added to the residue, the mixture is cooled, then filtered. The solid product is recrystallized from ethanol to provide 8-(2-methyl-1H-tetrazol-5-ylcarbamoyl)quinoline, m.p. 222-223 C.
 

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