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Chemical Structure| 857629-79-9 Chemical Structure| 857629-79-9

Structure of 857629-79-9

Chemical Structure| 857629-79-9

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Product Details of [ 857629-79-9 ]

CAS No. :857629-79-9
Formula : C16H19N3O5
M.W : 333.34
SMILES Code : O=C(N(CC)CC)/C(C#N)=C/C1=CC([N+]([O-])=O)=C(O)C(OCC)=C1

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Application In Synthesis of [ 857629-79-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 857629-79-9 ]

[ 857629-79-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 178686-24-3 ]
  • [ 26391-06-0 ]
  • (Z)-N,N-diethyl-2-cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)acrylamide [ No CAS ]
  • [ 857629-79-9 ]
YieldReaction ConditionsOperation in experiment
With piperidine; acetic acid; In toluene; at 100 - 115℃; for 15.0h;Heating / reflux; Charge <strong>[178686-24-3]3-ethoxy-4-hydroxy-5-nitrobenzaldehyde</strong> 20g (0. 0947mole) of the formula 2 where R= ethyl and N, N-diethylamino cyanoacetamide of the formula (3) 14. 6g, (0.1042), acetic acid 3.13g and piperidine 4.45g along with toluene 200ml and heated to reflux temperature of about 100-115 C with continuous removal of water azeotrophically 15 hours. After the reaction is over the reaction mixture is concentrated to a volume of 20-30ml quenched in to dilute hydrochloric acid and chilled water 200ml and stirred for 60 minutes. The precipitated solid was filtered and dried to get 30g (95%), the HPLC purity is 94% (including isomer) of N, N-DIETHYL - 2-CYANO-3- (-3-ETHOXY-4-HYDROXY-5 NITROPHENYL) ACRYLAMIDE. The product is used as such directly to the. next stage. MR = 110.1- 117. 2 C.
 

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