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Chemical Structure| 854305-91-2 Chemical Structure| 854305-91-2

Structure of 854305-91-2

Chemical Structure| 854305-91-2

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Product Details of [ 854305-91-2 ]

CAS No. :854305-91-2
Formula : C14H15N
M.W : 197.28
SMILES Code : NC1=C(C)C=CC=C1C2=CC=CC=C2C

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Application In Synthesis of [ 854305-91-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 854305-91-2 ]

[ 854305-91-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 53848-17-2 ]
  • [ 16419-60-6 ]
  • [ 854305-91-2 ]
YieldReaction ConditionsOperation in experiment
90% With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; In ethanol; water; toluene; at 90℃; for 12h;Inert atmosphere; Schlenk technique; Sealed tube; General procedure: An oven-dried Schlenk flask containing a magnetic stir bar was charged with the appropriateboronic acid (1.5 equiv), Pd2dba3 (2.0 mol%), S-Phos (8.0 mol%) and anhydrous K2CO3 (4.0equiv). The Schlenk flask was capped with a rubber septum and then evacuated and backfilledwith argon (this sequence was repeated three times). 2-Bromo anilines (1.0 equiv) intoluene/EtOH/H2O (8: 2: 2, 0.25 M) was added through the septum via syringe and the Schlenkflask was sealed. The reaction was stirred at 90 C for 12 h under argon atmosphere beforebeing allowed to cool to room temperature. The mixture was extracted with ethyl acetate, andthe combined organic layers were washed with H2O and brine, dried over anhydrous MgSO4,concentrated by rotary evaporation. The crude material was purified by flash chromatographyon silica gel to give the product.
 

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