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Chemical Structure| 85102-27-8 Chemical Structure| 85102-27-8

Structure of 85102-27-8

Chemical Structure| 85102-27-8

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Product Details of [ 85102-27-8 ]

CAS No. :85102-27-8
Formula : C13H10N2
M.W : 194.23
SMILES Code : C12=NC=CN1C=CC(C3=CC=CC=C3)=C2
MDL No. :MFCD09994636

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Application In Synthesis of [ 85102-27-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 85102-27-8 ]

[ 85102-27-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 4532-25-6 ]
  • [ 98-80-6 ]
  • [ 85102-27-8 ]
YieldReaction ConditionsOperation in experiment
70% With tris-(dibenzylideneacetone)dipalladium(0); sodium carbonate; tricyclohexylphosphine; In water; N,N-dimethyl-formamide; at 130℃; for 1h;Inert atmosphere; Microwave irradiation; General procedure: <strong>[4532-25-6]7-chloroimidazo[1,2-a]pyridine</strong> (5) (300 mg, 1.97 mmol) was dissolved in 8:1 DMF:H2O (13.1 mL) in a microwave vial affixed with a magnetic stir bar. Thiophen-2-ylboronic acid was added followed by sodium carbonate (834 mg, 7.86 mmol). The reaction mixture was degassed with argon. Pd2(dba)3 (36 mg, 0.039 mmol) and P(Cy)3 (33 mg, 0.118 mmol) was added to the reaction mixture and the vial was sealed. The reaction was heated by microwave irradiation to 130 C for 1 h. After, the reaction mixture was diluted with ethyl acetate and washed three times with saturated sodium bicarbonate and three times with deionized water. The organic layer was dried over anhydrous sodium sulfate and the solvent was removed in vacuo. The crude product was absorbed onto silica. The product was purified via flash chromatography utilizing a DCM/MeOH gradient and isolated as a brown solid (223 mg, 59%).
 

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