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Chemical Structure| 849208-76-0 Chemical Structure| 849208-76-0

Structure of 849208-76-0

Chemical Structure| 849208-76-0

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Product Details of [ 849208-76-0 ]

CAS No. :849208-76-0
Formula : C13H11NO2
M.W : 213.23
SMILES Code : O=C(C1=CC(C2=CC=CC=C2)=C(N)C=C1)O

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Application In Synthesis of [ 849208-76-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 849208-76-0 ]

[ 849208-76-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6311-37-1 ]
  • [ 98-80-6 ]
  • [ 849208-76-0 ]
YieldReaction ConditionsOperation in experiment
47% With potassium carbonate;bis-triphenylphosphine-palladium(II) chloride; In diethylene glycol dimethyl ether; water; for 18h;Heating / reflux; 4-Amino-3-bromo-benzoic acid (65 mmol), phenyl boronic acid (70 mmol), Pd (PPh3) 2Cl2 (3.2 mmol) and IZ2COs (140 mmol) was combined in a flask and refluxed in a mixture of ethylene glycol dimethyl ether (75 mL) and water (75 mL) under an argon atmosphere for 18h. The organic solvent was removed in vacuo and pH was adjusted to 4. The crude product was removed by filtration, re-dissolved in ethyl acetate, and passed through a silica plug to remove any Pd-residues. The filtrate was evaporated to dryness and re-crystallized from ethyl acetate/heptane to give off-white crystals. Yield: 47% NMR (D6-DMSO) : 5.56 (s, 2H); 6.78 (d, 1H); 7.30-7. 75 (8H); 12.09 (br, 1H).
 

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