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Chemical Structure| 847416-51-7 Chemical Structure| 847416-51-7

Structure of 847416-51-7

Chemical Structure| 847416-51-7

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Product Details of [ 847416-51-7 ]

CAS No. :847416-51-7
Formula : C11H16O4
M.W : 212.24
SMILES Code : O=C(C1CC(C1)=CC(OC(C)(C)C)=O)O
MDL No. :MFCD24496536

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Application In Synthesis of [ 847416-51-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 847416-51-7 ]

[ 847416-51-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 23761-23-1 ]
  • [ 62327-21-3 ]
  • [ 847416-51-7 ]
YieldReaction ConditionsOperation in experiment
Step 1: 3-tert-Butoxycarbonylmethylene-cyclobutanecarboxylic acid A mixture of 1.2 g of cyclobutanone-3-carboxylic acid (Pigou, P. E.; Shiesser, C. H.; J. Org. Chem.53, 3841-3, 1988), 2.8 g of tert-butyl-dimethyl phosphono-acetate, 1.0 g of lithium hydroxide which had been dried at 120° C. for 30 min under vacuum, 6 g of activated 4A (heated in microwave oven then dried under vacuum for 1 h) molecular sieve dust and 50 mL of THF was heated to reflux under nitrogen for 24 h, cooled, diluted with 100 mL of ethyl acetate and 100 mL of 1N HCl and filtered through diatomaceous earth. The layers were separated and the aqueous layer extracted 4*mL of ethyl acetate. The combined organic extracts were diluted with 50 mL of toluene and concentrated under reduced pressure. Drying under vacuum overnight gave 2 g of product as a white crystalline solid: 1H NMR (400 MHz, CDCl3) 5.5 (s, 1H), 3.9-3.0 (complex m, 4H), 1.42 (s, 9H).
 

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