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Chemical Structure| 845729-40-0 Chemical Structure| 845729-40-0

Structure of 845729-40-0

Chemical Structure| 845729-40-0

4-(2-Methyl-4-nitrophenyl)morpholin-3-one

CAS No.: 845729-40-0

4.5 *For Research Use Only !

Cat. No.: A506256 Purity: 95%

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Product Details of [ 845729-40-0 ]

CAS No. :845729-40-0
Formula : C11H12N2O4
M.W : 236.22
SMILES Code : O=C1N(C2=CC=C([N+]([O-])=O)C=C2C)CCOC1
MDL No. :MFCD27938917

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Application In Synthesis of [ 845729-40-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 845729-40-0 ]

[ 845729-40-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 109-11-5 ]
  • [ 455-88-9 ]
  • [ 845729-40-0 ]
YieldReaction ConditionsOperation in experiment
51% (b) 3-methyl-1-nitro-4-(3-oxo-morpholin-4-yl)-benzene 1.00 g (6.45 mmol) 4-fluoro-3-methyl-1-nitro-benzene is combined in 20 ml DMF with 281 mg (6.45 mmol) 55% sodium hydride, dispersed in paraffin, stirred for 5 min at ambient temperature. Then 815 mg (8.06 mmol) <strong>[109-11-5]morpholin-3-one</strong> were added and then stirred for 2 h at ambient temperature. Then the mixture is evaporated down i. vac., water is added to the residue and it is extracted with ethyl acetate. The combined organic phases are washed with sat. sodium chloride solution, dried on sodium sulphate, evaporated down i. vac. and the residue is purified by chromatography on silica gel (eluant gradient: cyclohexane/ethyl acetate=1:1→0:1). Yield: 780 mg (51%) Rf value: 0.52 (silica gel, ethyl acetate) C11H12N2O4 (236.22) Mass spectrum: (M+H)+=237
 

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