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Chemical Structure| 823221-96-1 Chemical Structure| 823221-96-1

Structure of 823221-96-1

Chemical Structure| 823221-96-1

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Product Details of [ 823221-96-1 ]

CAS No. :823221-96-1
Formula : C6H2ClF3IN
M.W : 307.44
SMILES Code : FC(C1=CC=C(Cl)C(I)=N1)(F)F
MDL No. :MFCD15478071

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Application In Synthesis of [ 823221-96-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 823221-96-1 ]

[ 823221-96-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 823221-95-0 ]
  • [ 823221-96-1 ]
YieldReaction ConditionsOperation in experiment
With lithium diisopropyl amide; In tetrahydrofuran; at -78℃; for 2h;Inert atmosphere; Step D 3-chloro-2-iodo-6-(trifluoromethyl)pyridine Into a 100 mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed a solution of <strong>[823221-95-0]5-chloro-4-iodo-2-(trifluoromethyl)pyridine</strong> (as prepared in the previous step, 2 g, 6.51 mmol, 1.00 equiv) in tetrahydrofuran (20 mL). This was followed by the addition of LDA (730 mg, 6.82 mmol, 1.05 equiv, as a THF solution) dropwise with stirring at -78 C. The resulting solution was stirred for 2 h at -78 C. The reaction was then quenched by the addition of 5 mL of water and diluted with 100 mL DCM. The resulting solution was washed with 50 mL brine, dried (Na2SO4), and concentrated. The residue was purified by silica gel column with ethyl acetate/petroleum ether (1:10) eluent, yielding 3-chloro-2-iodo-6-(trifluoromethyl)pyridine as a yellow solid.
 

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