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Chemical Structure| 81872-10-8 Chemical Structure| 81872-10-8
Chemical Structure| 81872-10-8

Zofenopril

CAS No.: 81872-10-8

Zofenopril is an inhibitor of angiotensin-converting enzyme (ACE) with IC50 of 81 μM.

Synonyms: Zofenopril

4.5 *For Research Use Only !

Cat. No.: A233362 Purity: 98%

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Product Citations

Product Citations

Roth, Lukas ; Gotsbacher, Michael P. ; Codd, Rachel ;

Abstract: Immobilized metal-ion affinity chromatog. (IMAC) used to purify recombinant proteins features a resin-bound 1:1 Ni(II)-iminodiacetic acid (IDA) complex. This hemi-saturated Ni(II)-IDA system containing exchangeable sites at the metal ion is re-cast as a surrogate of a coordinatively-unsaturated metalloenzyme active site, with utility for selecting compounds with metal-binding groups from mixtures as potential metalloenzyme inhibitors. Exchanging Ni(II) for other metal ions could broaden the scope of metalloenzyme target. This work examined the performance of Cu(II)-, Fe(III)-, Ga(III)-, Ni(II)-, or Zn(II)-IMAC resins to reversibly bind exptl. or clin. metalloenzyme inhibitors of Zn(II)-ACE1, Zn(II)-HDAC, Fe(II)/(III)-5-LO or Cu(II)-tyrosinase from a curated mixture (1-17). Each IMAC system gave a distinct selection profile. The Zn(II)-IMAC system selectively bound the thiol-containing Zn(II)-ACE1 inhibitors captopril and omapatrilat, and the Fe(III)-IMAC system selectively bound the Fe(II)/(III)-5-LO inhibitor licofelone, demonstrating a remarkable IMAC-metalloenzyme metal ion match. IMAC provides a simple, water-compatible platform, which could accelerate metalloenzyme inhibitor discovery.

Purchased from AmBeed: ; ; ; 76420-72-9 ;

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Product Details of Zofenopril

CAS No. :81872-10-8
Formula : C22H23NO4S2
M.W : 429.55
SMILES Code : O=C([C@H]1N(C([C@H](C)CSC(C2=CC=CC=C2)=O)=O)C[C@@H](SC3=CC=CC=C3)C1)O
Synonyms :
Zofenopril
MDL No. :MFCD00870957

Safety of Zofenopril

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.33mL

0.47mL

0.23mL

11.64mL

2.33mL

1.16mL

23.28mL

4.66mL

2.33mL

 

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