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Chemical Structure| 81778-09-8 Chemical Structure| 81778-09-8

Structure of 81778-09-8

Chemical Structure| 81778-09-8

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Product Details of [ 81778-09-8 ]

CAS No. :81778-09-8
Formula : C7H5BrClF
M.W : 223.47
SMILES Code : FC1=CC=C(Cl)C(CBr)=C1
MDL No. :MFCD01631419
InChI Key :AUVLFQDKJFSFIX-UHFFFAOYSA-N
Pubchem ID :2773623

Safety of [ 81778-09-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H314
Precautionary Statements:P210-P280-P305+P351+P338-P310
Class:3(8)
UN#:2924
Packing Group:

Application In Synthesis of [ 81778-09-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 81778-09-8 ]

[ 81778-09-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 261762-59-8 ]
  • [ 81778-09-8 ]
YieldReaction ConditionsOperation in experiment
With phosphorus tribromide; In 1,2-dimethoxyethane; at 0 - 20℃; for 3h; To a solution of <strong>[261762-59-8](2-chloro-5-fluorophenyl)methanol</strong> (24, 25.5 g, 159 mmol) in dry DME (200 mL) at 0 C. was added a solution of PBr3 (25.8 g, 95.2 mmol) in dry DME (150 mL) dropwise. The mixture was then slowly warmed up to RT and stirred at RT for another 3 h. The mixture was diluted with water (300 mL), and extracted with 1:1 petroleum-ether-EtOAc (200 mL×2). The combined extracts were washed with saturated NaHCO3 and brine, dried over MgSO4, and concentrated to give 2-(bromomethyl)-1-chloro-4-fluorobenzene (25).
 

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