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Chemical Structure| 791632-21-8 Chemical Structure| 791632-21-8

Structure of 791632-21-8

Chemical Structure| 791632-21-8

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Product Details of [ 791632-21-8 ]

CAS No. :791632-21-8
Formula : C10H6BrNO2
M.W : 252.06
SMILES Code : O=C(O)C1=CC(Br)=C2N=CC=CC2=C1
MDL No. :MFCD09754138

Safety of [ 791632-21-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Application In Synthesis of [ 791632-21-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 791632-21-8 ]

[ 791632-21-8 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 6311-37-1 ]
  • [ 62-23-7 ]
  • [ 791632-21-8 ]
YieldReaction ConditionsOperation in experiment
25% With ferrous(II) sulfate heptahydrate; sulfuric acid; boric acid; In glycerol; at 140℃; for 42h;Inert atmosphere; To a mixture of <strong>[6311-37-1]4-amino-3-bromobenzoic acid</strong> (500 mg, 2.31 mmol) in concentrated sulfuric acid (650 muL) was added glycerol (1.75 g, 19.0 mmol), 4-nitrobenzoic acid (391 mg, 2.34 mmol), boric acid (215 mg, 3.48 mmol) and iron(II) sulfate heptahydrate (234 mg, 0.842 mmol), and the reaction was stirred at 140 C. for 42 h. The reaction mixture was cooled to room temperature and the pH was adjusted to 10 with 10% sodium hydroxide. The aqueous layer was extracted with ethyl acetate (2*100 mL) and the combined organic layers were dried over sodium sulfate, filtered and evaporated to give the title compound (150 mg, 25% yield) as a 10 yellow powder. MS (ESI): mass calcd. for C10H6 BrNO2, 251.0; m/z found, 252.0 [M+H]+.
 

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