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Chemical Structure| 782493-64-5 Chemical Structure| 782493-64-5

Structure of 782493-64-5

Chemical Structure| 782493-64-5

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Product Details of [ 782493-64-5 ]

CAS No. :782493-64-5
Formula : C16H25N3O4
M.W : 323.39
SMILES Code : O=C(N1CCC(N2N=CC(C(OCC)=O)=C2)CC1)OC(C)(C)C
MDL No. :MFCD11501921
InChI Key :SWDVDDQIYQRMHZ-UHFFFAOYSA-N
Pubchem ID :45926154

Safety of [ 782493-64-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 782493-64-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 782493-64-5 ]

[ 782493-64-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5932-27-4 ]
  • [ 141699-59-4 ]
  • [ 782493-64-5 ]
YieldReaction ConditionsOperation in experiment
87% With caesium carbonate; In N,N-dimethyl-formamide; at 5 - 90℃; To a stirred solution of ethyl-I-H pyrazole carboxylate (5.0 g, 3.7mmol) in DMF (50 mL),Cs2CO3 (23 g, 71.3Smmol) and tert-butyl 4-((methylsulfonyl)-oxy) piperidine-I-carboxylate(9.9 g, 35.6 mmol) were added at 5 °C and reaction mixture was stirred at 90 °C overnight.The completion of the reaction was confirmed by TLC. The reaction mixture was pouredinto ice cold water. The resulting solid was filtered, washed with water (50 mL) and driedunder reduced pressure. It was used in the next step without any further purification. Yield:87percent (10 g, off white solid). 1H NMR (400 MHz, DMSO-d6 : 6 8.39 (5, IH), 7.87 (5, IH),4.45-4.39 (m, IH), 4.21 (q, J= 7.2 Hz, 2H), 4.05-4.02 (m, 2H), 2.01-1.98 (m, 2H), 1.85-1.78 (m, 2H), 1.42 (5, 9H), 1.26 (t, J = 7.2 Hz, 3H). LCMS: (Method A) 222.0 (M-Boc), Rt. 2.77 mm, 92.86percent (Max).
 

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