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Chemical Structure| 782434-80-4 Chemical Structure| 782434-80-4

Structure of 782434-80-4

Chemical Structure| 782434-80-4

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Product Details of [ 782434-80-4 ]

CAS No. :782434-80-4
Formula : C6H5BrN2O2
M.W : 217.02
SMILES Code : O=C(C1=NC=C(CBr)N=C1)O
MDL No. :MFCD14584502

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Application In Synthesis of [ 782434-80-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 782434-80-4 ]

[ 782434-80-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 193966-70-0 ]
  • [ 782434-80-4 ]
YieldReaction ConditionsOperation in experiment
37% With potassium trimethylsilonate; In tetrahydrofuran; at 70℃; for 0.75h; [0139j To a solution of <strong>[193966-70-0]methyl 5-(bromomethyl)pyrazine-2-carboxylate</strong> (0.5 g, 2.16 mmol) in tetrahydrofuran (20 mL) was added potassium trimethylsilanolate (0.11 g, 0.80 mmol) and the reaction mixture was stirred at 70 C for 45 minutes. The reaction mixture was diluted with water (30 mL), acidified with 1.5 M hydrochloric acid (pH 2-3) and extracted with ethyl acetate (50 mL x 3). The combined organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The crude was purified by silica gel column chromatography using 3% methanol in dichloromethane as eluant, to afford the title compound 5-(bromomethyl)pyrazine-2-carboxylic acid (0.174 g, 37% yield) as a yellow solid. Calculated M+H: 218.02; Found M+H: 218.1.
 

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