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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 77797-64-9 Chemical Structure| 77797-64-9

Structure of 77797-64-9

Chemical Structure| 77797-64-9

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Product Details of [ 77797-64-9 ]

CAS No. :77797-64-9
Formula : C7H3Cl2F3O3S
M.W : 295.05
SMILES Code : O=S(C1=CC(Cl)=CC=C1OC(F)(F)F)(Cl)=O
MDL No. :MFCD18393795

Safety of [ 77797-64-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 77797-64-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 77797-64-9 ]

[ 77797-64-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 326-64-7 ]
  • [ 77797-64-9 ]
YieldReaction ConditionsOperation in experiment
a) 5-chloro-2-(trifluoromethoxy)benzene-1-sulfonyl Chloride Thionyl chloride (2.2 mL) was added dropwise to water (2.2 mL) at 0 C. The mixture was stirred for 16 hr at room temperature. Copper(I) chloride (23 mg) was added and the mixture was cooled to 0 C. to give solution A. A solution of sodium nitrite (179 mg) in water (2.2 mL) was added dropwise to a mixture of <strong>[326-64-7]5-chloro-2-(trifluoromethoxy)aniline</strong> (500 mg) and concentrated hydrochloric acid (2.2 mL) at 0 C. The mixture was stirred at 0 C. for 30 min to give mixture B. Mixture B was added to solution A at 0 C. The mixture was stirred at 0 C. for min, diluted with water, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, dried over magnesium sulfate and concentrated to give a residue. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give a crude purified product of the title compound (233 mg). MS, found: [M-H]-275.0.
 

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