Home Cart Sign in  
Chemical Structure| 773887-11-9 Chemical Structure| 773887-11-9

Structure of 773887-11-9

Chemical Structure| 773887-11-9

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 773887-11-9 ]

CAS No. :773887-11-9
Formula : C11H12N2O
M.W : 188.23
SMILES Code : O=CC1=CC2=C(NN=C2)C(C(C)C)=C1

Safety of [ 773887-11-9 ]

Application In Synthesis of [ 773887-11-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 773887-11-9 ]

[ 773887-11-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 773887-09-5 ]
  • [ 773887-11-9 ]
YieldReaction ConditionsOperation in experiment
2.1 g (92%) With hydrogenchloride; sec.-butyllithium; sodium hydrogencarbonate; In tetrahydrofuran; N-methyl-acetamide; cyclohexane; 7-Isopropyl-1H-indazole-5-carbaldehyde <strong>[773887-09-5]5-Bromo-7-isopropyl-1H-indazole</strong> (3.1 g, 12.1 mmol) and sodium hydride (0.34 g, 1.1 equiv.) were weighed into a flame-dried round-bottom flask containing a magnetic stir bar. Under a nitrogen atmosphere at room temperature, dry tetrahydrofuran (18 mL) was added. The mixture was stirred at room temperature for 15 min, during which time it became homogeneous. The stirred mixture was cooled to -78 C. and a solution of sec-butyllithium in cyclohexane (1.4M, 20 mL, 2.2 equiv.) was added over several minutes. After 1 h at -78 C., dimethylformamide (3.0 mL) was slowly added and the mixture allowed to warm to room temperature overnight. The solution was cooled to 0 C. and carefully treated with 1 N hydrochloric acid (35 mL). After a few minutes, solid sodium bicarbonate was added until a pH of 9-10 was attained. The two layers were separated and the aqueous phase washed twice with ethyl acetate. The combined organic layers were washed with water (2*), brine (2*), dried over sodium sulfate, and concentrated. Column chromatography gave 2.1 g (92%) of pure material. LC/MS: tR=1.15 min, 189.12 (MH)+.
  • 2
  • [ 773887-09-5 ]
  • [ 68-12-2 ]
  • [ 773887-11-9 ]
 

Historical Records