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Chemical Structure| 77317-53-4 Chemical Structure| 77317-53-4

Structure of 77317-53-4

Chemical Structure| 77317-53-4

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Product Details of [ 77317-53-4 ]

CAS No. :77317-53-4
Formula : C13H11BrO
M.W : 263.13
SMILES Code : CC1=CC(OC2=CC=CC=C2)=CC=C1Br

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Application In Synthesis of [ 77317-53-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 77317-53-4 ]

[ 77317-53-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13024-16-3 ]
  • [ 77317-53-4 ]
YieldReaction ConditionsOperation in experiment
60% A suspension of <strong>[13024-16-3]2-methyl-4-phenoxyaniline</strong> (19 g, 95.5 mmol) in water (375 mL) was added HBr (150 mL, 40%) at 0C. After 30 min, NaN02 (6.9 g, 100 mmol) in water (75 mL) was added at 0 C. After 30 min, the mixture was added to a pre-heated suspension of CuBr (14.3 g, 100 mmol) in water (375 mL) at 65 C. The mixture was stirred at 65 C for 30 min, cooled, and extracted with petroleum ether. The combined organic layer was washed with water and dried over Na2S04. Purification by silica gel column chromatography afforded 1- bromo-2-methyl-4-phenoxybenzene (15 g, 60%) as a yellow oil.
 

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