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Chemical Structure| 76274-94-7 Chemical Structure| 76274-94-7

Structure of 76274-94-7

Chemical Structure| 76274-94-7

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Product Details of [ 76274-94-7 ]

CAS No. :76274-94-7
Formula : C10H9ClO
M.W : 180.63
SMILES Code : O=C(Cl)C1=CC=C(C2CC2)C=C1
MDL No. :MFCD24849273

Safety of [ 76274-94-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H314-H331
Precautionary Statements:P260-P264-P270-P271-P280-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P310-P403+P233-P405-P501
Class:8(6.1)
UN#:2922
Packing Group:

Application In Synthesis of [ 76274-94-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 76274-94-7 ]

[ 76274-94-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1798-82-9 ]
  • [ 76274-94-7 ]
YieldReaction ConditionsOperation in experiment
With oxalyl dichloride; In dichloromethane; (b) 4-Acetylphenyl 4-cyclopropylbenzoate (Hf).; Oxalyl chloride(2.92 g, 22.2 mmol) was added dropwise to a solution of 4- cyclopropyl-benzoic acid (1.20 g, 7.4 mmol) in dichloromethane. The solution was allowed to stir overnight and the solvent was removed under reduced pressure. The acid chloride was then carried on crude.4-Hydroxyacetophenone (1.01 g, 7.4 mmol) was added to a slurry of NaH (60% in mineral oil, 296 mg, 7.4 mmol) in dichloromethane and allowed to stir for 10 min. 4-Cyclopropyl-benzoyl chloride (1.33 g, 7.4 mmol) was then added and the solution was allowed to stir for 3h. The reaction was then quenched with water and extracted three times with dichloromethane. The combined organic layers were then dried over magnesium sulfate, filtered and evaporated under reduced pressure to yield 1.83 g (88% over two steps). <n="63"/>1HNMR (CDCl3): delta 8.07 (t, J=8.7 Hz, 4H), 7.31 (d, J=8.4 Hz, 2H), 7.17 (d, J=8.4 Hz, 2H), 2.62 (s, 3H), 1.98 (sept, J=5.1 Hz, IH), 1.10 (m, 2H), 0.82 (m, 2H). 13CNMR (CDCl3): delta 196.91, 164.60, 154.77, 151.36, 134.61, 130.30, 129.94, 125.91, 125.55, 121.95, 26.62, 15.85, 10.61.
 

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