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Chemical Structure| 762286-20-4 Chemical Structure| 762286-20-4

Structure of 762286-20-4

Chemical Structure| 762286-20-4

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Product Details of [ 762286-20-4 ]

CAS No. :762286-20-4
Formula : C12H9F3N2O2
M.W : 270.21
SMILES Code : O=C(C1=CNC(C2=CC=C(C(F)(F)F)C=C2)=N1)OC
MDL No. :MFCD17047163

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Application In Synthesis of [ 762286-20-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 762286-20-4 ]

[ 762286-20-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 51579-10-3 ]
  • [ 38980-96-0 ]
  • [ 762286-20-4 ]
YieldReaction ConditionsOperation in experiment
11% With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 150℃; for 0.333333h;Irradiation; To a microwave reaction vial was added methyl 2-chloro-3-hydroxypropenoate (64a, 182.5 mg, 1.3 mmol), 4-trifluoromethylphenyl AMIDINE hydrochloride dihydrate (360.0 mg, 1.4 mmol), diisopropylethylamine (0.3 mL, 1.7 mmol), dry acetonitrile (3 mL) and a stir bar. The vial was sealed and irradiated under focused microwave energy for 20 minutes holding at 150 C. The solution was concentrated under a stream of nitrogen, diluted with methanol, filtered and purified by PREP LCMS. The above REACTION/PURIFICATION sequence was repeated to obtain a combined 121.2 mg (11 %) of the TFS SALT OF 6DB. LC-MS 271. 0 (MH+).
 

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