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Chemical Structure| 76053-43-5 Chemical Structure| 76053-43-5

Structure of 76053-43-5

Chemical Structure| 76053-43-5

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Product Details of [ 76053-43-5 ]

CAS No. :76053-43-5
Formula : C11H8ClNO
M.W : 205.64
SMILES Code : OC1=NC=C(C2=CC=C(Cl)C=C2)C=C1
MDL No. :MFCD11876521

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Application In Synthesis of [ 76053-43-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 76053-43-5 ]

[ 76053-43-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13472-79-2 ]
  • dry-MeOH [ No CAS ]
  • tetrakis-triphenylphosphane-palladium [ No CAS ]
  • [ 274251-56-8 ]
  • [ 76053-43-5 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate; In 1,4-dioxane-and; water; 10a 5-(4-chloro-phenyl)-pyridin-2-ol Under an N2 atmosphere 21.7 mL 2 M Na2CO3 solution and 250 mg (0.22 mmol) tetrakis-triphenylphosphane-palladium are added to a solution of 8.0 g (21.7 mmol) <strong>[13472-79-2]5-iodo-pyridin-2-ol</strong> and 3.81 g (23.9 mmol) 4-chlorophenyl-boric acid in 120 mL 1,4-dioxane-and 30 mL dry-MeOH and the reaction mixture is stirred for 19 h at 110 C. The mixture is evaporated down i.vac., the residue is combined with water, the precipitate is filtered off, washed with water and dried at 40 C. in the circulating air dryer until a constant weight is obtained. Yield: 3.8 g (85.1% of theory). C11H8ClNO (M=205.646).
 

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